Results from 3,263 QuantiFERON-TB Gold in-tube (QFT-GIT) assays were analyzed to determine the impact of age on test performance. The proportion of indeterminate results was significantly higher in pediatric and elderly (9.1% and 7.4%, respectively) than in adult (2.6%; chi-square test, P < 0.0001) patients. A detailed analysis of indeterminate QFT-GIT assay results is presented.

An effort was made to differentiate indeterminate (IND) leprosy from other types of the paucibacillary (PB) group of leprosy and to identify among indeterminate leprosy cases those which may evolve to multibacillary (MB) leprosy, using serological, immunological and histochemical parameters. A total of 92 untreated, histologically classified (TT-19, BT-30, IND-32) patients, including 11 cases d...

An integer array y = y[1..n] is said to be feasible if and only if y[1] = n and, for every i ∈ 2..n, i ≤ i+y[i] ≤ n+1. A string is said to be indeterminate if and only if at least one of its elements is a subset of cardinality greater than one of a given alphabet Σ; otherwise it is said to be regular. A feasible array y is said to be regular if and only if it is the prefix array of some regular...

In vitro gamma interferon release assays (IGRAs) are increasingly used as an alternative to the traditional tuberculin skin test for the diagnosis of latent Mycobacterium tuberculosis infection. Evaluation of the QuantiFERON-TB Gold in-tube assay (QFT-IT) prior to large-scale implementation at the Stanford Hospital and Clinics for a health care worker screening program revealed a critical prean...

Background Tumor necrosis factor alpha (TNFα) is a key cytokine in both the pathogenesis of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) and the host defense against tuberculosis (TB). Consequently, anti-TNFα medications result in an increased risk of latent TB infection (LTBI) reactivation. Here, we sought to evaluate the factors affecting the results of QuantiFERON-TB Gold I...

On the orthodox view in economics, interpersonal comparisons of utility are not empirically meaningful, and "hence" impossible. To reassess this view, this paper draws on the parallels between the problem of interpersonal comparisons of utility and the problem of translation of linguistic meaning, as explored by Quine. I discuss several cases of what the empirical evidence for interpersonal com...

In many temporally oriented applications, it is known that events have occurred but the exact time when an event has occurred is not known. For example, a blood test of a diabetic patient may yield information that the patient's blood glucose level is above the safe threshold but may not exactly tell when that has happened. Such temporal events are said to have valid-time indeterminacy, where t...

JOHN DILWORTH Department of Philosophy, Western Michigan University, Kalamazoo, Michigan 49008, USA. (E-mail: [email protected]) [Phenomenology and the Cognitive Sciences 6 (2007), pp. 369-387. The original publication is available at www.springerlink.com] Abstract. Representationalists currently cannot explain counter-examples that involve indeterminate perceptual content, but a double conten...

Sentences such as The author started the book are indeterminate because they do not make explicit what the subject (the author) started doing with the object (the book). In principle, indeterminate sentences allow for an infinite number of interpretations. One theory, however, assumes that these sentences are resolved by semanticcoercion, a linguistic process that forces the noun book to be int...

BACKGROUND Cytologically indeterminate thyroid nodules represent a diagnostic and therapeutic challenge. In 2007, the National Cancer Institute recommended The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) as a means of improving the accuracy of thyroid cytopathology. Our objective was to determine the effect of TBSRTC on thyroidectomy rates and malignancy risk in cytologically i...