Parkinson's disease (PD), the second most frequent neurodegenerative disease, fits within the wide range of complex polygenic disorders influenced by both genetic and environmental factors. In fact, just around 10% of PD cases are familial, caused by monogenic forms which sometimes exhibit incomplete penetrance. The vast majority of PD cases are sporadic and often present with varied clinical p...

This paper deals with data (or information) fusion for the purpose of estimation. Three estimation fusion architectures are considered: centralized, distributed, and hybrid. A unified linear model and a general framework for these three architectures are established. Optimal fusion rules based on the best linear unbiased estimation (BLUE), the weighted least squares (WLS), and their generalized...

Kawasaki disease (KD) is a common medium vessel systemic vasculitis that usually occurs in small children. It has a predilection for the coronary arteries, but other medium sized arteries can also be involved. The etiology of this disorder remains a mystery. Though typical presentation of KD is quite characteristic, it may also present as incomplete or atypical disease in which case the diagnos...

BACKGROUND Dystonia and tremor share many commonalities. Isolated tremor is part of the phenomenological spectrum of isolated dystonia and of essential tremor. The occurrence of subtle features of dystonia may allow one to differentiate dystonic tremor from essential tremor. Diagnostic uncertainty is enhanced when no features of dystonia are found in patients with a tremor syndrome, raising the...

the conditions under which, multilinear forms (the symmetric case and the non symmetric case),can be written as a product of linear forms, are considered. also we generalize a result due to s.kurepa for 2n-functionals in a group g.

The representation and manipulation of natural human understanding of temporal phenomena is a fundamental field of study in Computer Science, which aims both to emulate human thinking, and to use the methods of human intelligence to underpin engineering solutions. In particular, in the domain of Artificial Intelligence, temporal knowledge may be uncertain and incomplete due to the unavailabilit...

Under the conditions normally used for detritylation in oligonucleotide synthesis, the haloacetic acid binds strongly to the oligonucleotide. Acetonitrile also forms a complex with the deblocking acid, in competition with the oligonucleotide, and drastically slows detritylation. Incomplete removal of acetonitrile during the deblock step may slow the kinetics enough to result in incomplete detri...

Even under polynomial restrictions on plan length, conformant planning remains a very hard computational problem as plan verification itself can take exponential time. This heavy price cannot be avoided in general although in many cases conformant plans are verifiable efficiently by means of simple forms of disjunctive inference. We report an efficient but incomplete planner capable of solving ...