The effects of in vivo modulation of HDL phospholipid (PL) on scavenger receptor class BI (SR-BI)- and ATP binding cassette transporter 1 (ABCA1)-mediated efflux were examined by overexpressing either endothelial lipase (EL) or phosphatidylserine phospholipase (PS-PLA1) in human apolipoprotein A-I (apoA-I) transgenic mice. Overexpression of EL led to large reductions in the serum PL/apoA-I rati...

Storage phosphor computed radiography (SR) and flat-panel detector (FPD) radiography are two types of digital X-ray utilizing different techniques. We compared these two techniques with conventional analogue chest radiograph (AR) among pneumoconiotic patients and healthy controls. Thirty individuals consisting of 20 silica-exposed ex-workers and 10 healthy controls without occupational exposure...

Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown. One possibility, demonstrated in peripheral tissue cell lines, is that apoE stimulates nitric oxide synthase (NOS) via a receptor-dependent signalling pathway and that apoE4 generates inappropriate amounts of nitric oxide (NO) comp...

The bulk of the Ca 2 that activates contraction in the heart comes from the sarcoplasmic reticulum (SR). Calcium is released by the process of Ca -induced Ca release (CICR) in which the entry of a small amount of Ca across the cell membrane triggers the release of much more from the SR. This mechanism depends on the fact that Ca entry from the extracellular fluid (via the L-type Ca current) inc...

Diabetic heart disease is a distinct clinical entity that can progress to heart failure and sudden death. However, the mechanisms responsible for the alterations in excitation-contraction coupling leading to cardiac dysfunction during diabetes are not well known. Hyperglycemia, the landmark of diabetes, leads to the formation of advanced glycation end products (AGEs) on long-lived proteins, inc...

Agonist-stimulated waves of elevated cytoplasmic Ca concentration ([Ca]i) regulate blood vessel tone [1] and vasomotion [2] in vascular smooth muscle. Previous studies employing cytoplasmic Ca indicators revealed that these Ca waves were generated by a combination of inositol 1,4,5-trisphosphate (IP3) and Ca induced Ca release (CICR) from the sarcoplasmic reticulum (SR) [3, 4]; although, some o...

Cytosolic-free calcium (Ca 2 ) is a multifunctional intracellular messenger that regulates many different cellular processes in cardiac myocytes.1 A transient rise in intracellular free Ca concentrations ([Ca ]i) during excitationcontraction (E-C) coupling is required for initiating contraction of cardiac muscle. Membrane depolarization activates voltage-gated L-type Ca channels within the tran...

The recent phenomenal interest in convolutional neural networks (CNNs) must have made it inevitable for the super-resolution (SR) community to explore its potential. The response has been immense and in the last three years, since the advent of the pioneering work, there appeared too many works not to warrant a comprehensive survey. This paper surveys the SR literature in the context of deep le...

The third-generation synchrotron radiation (SR) facilities are storage ring-based facilities with many insertion devices and photon beamlines, and have low injection beam power, but extremely high stored beam power. The fourth-generation X-ray free electron laser (FEL) facilities are based on an electron Linac with a long undulator and have high injection beam power. Due to its electron and pho...

Automated document classification can be a valuable tool for enhancing the efficiency of creating and updating systematic reviews (SRs) for evidence-based medicine. One way document classification can help is in performing work prioritization: given a set of documents, order them such that the most likely useful documents appear first. We evaluated several alternate classification feature syste...