Generation of three dimensional structures of macromolecules using in silico structural modeling technologies such as homology and de novo modeling has improved dramatically and increased the speed by which tertiary structures of organisms can be generated. This is especially the case if a homologous crystal structure is already available. High-resolution structures can be rapidly created using...

Abstract Magnetic nanodisks have been recently proposed as biomedical tools for therapeutics at the nanoscale level, with a special focus on hyperthermia cancer cure. Here we present detailed study of permalloy to be used in alternative superparamagnetic iron oxide nanoparticles, efficient heating agents that release heat via magnetic hysteresis. A micromagnetic modeling analysis is carried out...

The knee joint is a complex biomechanical subsystem, modeling of which can reveal deeper understanding the processes occurring within it. purpose this study to examine stress alteration in bone based on mechanical properties cartilage. To achieve this, numerical model was developed and tested under different displacement values. behavior represented by considering hyperelastic soft tissues, alo...

Background: The electrical conductivity of trabecular bone at 100 kHz has recently been reported as a good predictor volume fraction. However, quantifying its relationship with free water (or physiological solution) content and the conductivities constituents is still difficult. Methods: In this contribution, in silico models inspired by microCT images bovine samples were used to build realisti...

Rational engineering methods can be applied with reasonable success to optimize physicochemical characteristics of proteins, in particular, antibodies. Here, we describe a combined CDR3 walking randomization and rational design-based approach to enhance the affinity of the human anti-gastrin TA4 scFv. The application of this methodology to TA4 scFv, displaying only a weak overall affinity for g...