Intensity-modulated radiation therapy (IMRT) quality assurance (QA) is often performed using a 2D device and compares measured and computed fluence maps to determine if a field passes or fails certain dose and position criteria. The effects of a measured deviation to the 3D patient spatial dosimetry and dose volume histogram (DVH) are largely unknown because they cannot be analyzed using commer...

AIMS Speckle tracking echocardiography has already demonstrated its clinical potential. However, its use in routine practice is jeopardized by recent reports on high inter-vendor variability of the measurements. As such, the European Association of CardioVascular Imaging (EACVI) and the American Society of Echocardiography (ASE) set up a standardization task force, which was joined by all manuf...

The purpose of this study is to evaluate the use of the Dosimetry Check system for patient-specific IMRT QA. Typical QA methods measure the dose in an array dosimeter surrounded by homogenous medium for which the treatment plan has been recomputed. With the Dosimetry Check system, fluence measurements acquired on a portal dosimeter is applied to the patient's CT scans. Instead of making dose co...

The aim of this document is to define the quality assurance (QA) methods for scanners using the ice-water phantom and the corresponding software developed within the IMI QuIC-ConCePT project, for the upcoming ‘BOS2’ trials. The outlined methods are what we consider to constitute the best use of currently available data following our recent papers [1] [2] in which we studied ADC (apparent diffus...

The field of Question Answering (QA) is very multi-disciplinary as it requires expertise from a large number of areas such as natural language processing (NLP), artificial intelligence, machine learning, information retrieval, speech recognition and semantic technologies. In the past years a large number of QA systems were proposed using approaches from different fields and focusing on particul...

This work aims at three goals: first, to define a set of statistical parameters and plan structures for a 3D pretreatment thoracic and prostate intensity-modulated radiation therapy (IMRT) quality assurance (QA) protocol; secondly, to test if the 3D QA protocol is able to detect certain clinical errors; and third, to compare the 3D QA method with QA performed with single ion chamber and 2D gamm...

Continuous Delivery is aimed at the frequent delivery of good quality software in a speedy, reliable and efficient fashion – with strong emphasis on automation and team collaboration. However, even with this new paradigm, repeatability of project outcome is still not guaranteed: project performance varies due to the various interacting and interrelated factors in the Continuous Delivery 'system...

The loading of MHC class I molecules with peptides involves a variety of accessory proteins, including TAP-associated glycoprotein (tapasin), which tethers empty MHC class I molecules to the TAP peptide transporter. We have evaluated the role of tapasin for the assembly of peptides with the class Ib molecule Qa-1b. In normal cells, Qa-1b is predominantly bound by a peptide, the Qa-1 determinant...

A respiratory training system based on audiovisual biofeedback has been implemented at our institution. It is intended to improve patients' respiratory regularity during four-dimensional (4D) computed tomography (CT) image acquisition. The purpose is to help eliminate the artifacts in 4D-CT images caused by irregular breathing, as well as improve delivery efficiency during treatment, where resp...

Cardiovascular perfusionists have always been interested in quality assurance (QA), most often in the form of equipment maintenance and record keeping. However, these activities have tended to be fragmented. In an attempt to define a more global approach to QA, basic concepts are identified and the steps used to start a formal QA program are illustrated. In the usual approach to QA, three area...