Orally inhaled therapies are a cornerstone of lung health maintenance in CF. Topical application of drugs in the airways increases the efficacy and reduces the systemic exposure and toxicity of these agents. Most CF patients are treated with aerosolized therapies, and many take multiple inhaled drugs on a daily basis. Treatments for bronchodilation, inflammation, airway clearance and early or c...

Double disks synergy test (DDST) and combined disks test (CD) were evaluated to predict the presence of metallo-β-lactamase in 70 Pseudomonas aeruginosa isolates recovered from cystic fibrosis and non-cystic fibrosis patients. DDST(CAZ-EDTA 1 cm) and CD(IMP-EDTA) tests showed the best accuracy (94.3%). Furthermore, for other combinations, accuracy unsatisfactory was obtained.

This paper aimed at examining the Iranian EFL teachers and learners’ preferences for two types of direct oral corrective feedback, including explicit correction and metalinguistic clues, and two types of indirect oral corrective feedback, including recast and repetition. The participants included 39 teachers and 84 EFL learners, selected through purposive sampling. A scenario-based questionnair...

Calcium mobilization can regulate a wide range of essential functions of respiratory epithelium, including ion transport, ciliary beat frequency, and secretion of mucus, all of which are modified in cystic fibrosis (CF). SERCA2, an important controller of calcium signaling, is deficient in CF epithelium. We conducted this study to determine whether SERCA2 deficiency can modulate airway epitheli...

Background: Many studies have shown that CFRD has a negative impact on CF prognosis. Current guidelines advise to screen for CFRD with an OGTT yearly from the age of 10 12. In our center we do not routinely screen for CFRD because the OGTT is cumbersome and not an ideal screening test. We therefore want to exclude unfavourable clinical evolution due to late diagnosis. Methods: 23 CF patients wi...

Everything should be made as simple as possible, but not simpler.

The paper presents a novel approach for accurate polygonization of implicit surfaces with sharp features. The approach is based on mesh evolution towards a given implicit surface with simultaneous control of the mesh vertex positions and mesh normals.

ozone modification method and air-oxidation were used for the surface treatment of polyacrylonitrile(pan)-based carbon fiber. the surface characteristics of carbon fibers were characterized by x-ray photoelectron spectroscopy (xps). the interfacial properties of carbon fiber reinforced polyamide 6 (cf/pa6) composites were investigated by means of the single fiber pull-out tests. as a result, it...