Mitochondria, the cellular powerhouses, are mandatory to keep eukaryotic cells alive. The function of these organelles has to be regulated carefully, as they also have an important impact on the regulation of cell death programs and aging. In the past few years, it became clear that the dynamic morphology changes of mitochondria by division and fusion events play a crucial role in controlling m...

Diet induced obesity is associated with impaired mitochondrial function and dynamic behavior. Mitochondria are highly dynamic organelles and the balance in fusion/fission is strictly associated with their bioenergetics. Fusion processes are associated with the optimization of mitochondrial function, whereas fission processes are associated with the removal of damaged mitochondria. In diet-induc...

With exposure to air, many liquid metals spontaneously generate an oxide layer on their surface. In oscillatory rheological tests, this skin is found to introduce a yield stress that typically dominates the elastic response but can be tuned by exposing the metal to hydrochloric acid solutions of different concentration. We systematically studied the normal impact of eutectic gallium-indium (eGa...

We perform an experimental study of granular impact, where intruders strike 2D beds of photoelastic disks from above. High-speed video captures the intruder dynamics and the local granular force response, allowing investigation of grain-scale mechanisms in this process. We observe rich acoustic behavior at the leading edge of the intruder, strongly fluctuating in space and time, and we show tha...

We use aerosol techniques to investigate the cohesive and granular properties of solids composed of colloidal semiconductor nanocrystals (quantum dot solids). We form spherical agglomerates of nanocrystals with a nebulizer and direct them toward a carbon substrate at low (~0.01 m/s) or high (~100 m/s) velocities. We then study the morphology of the deposit (i.e., the "splat") after impact. By v...

serum albumin is the most aboundant protein in blood plasma. its two major roles aremaintaining osmotic pressure and depositing and transporting compounds. in this paper,albumin-methanol solution simulation is carried out by three techniques including montecarlo (mc), molecular dynamic (md) and langevin dynamic (ld) simulations. byinvestigating energy changes by time and temperature (between 27...

the current study aimed to define some factors contributing to implicit attitude formation mainly in the social interaction context. an agent-based computer simulation of a society including autonomous agents and an attitude object was used to track the implicit attitude progress towards the object. the society could simulate the autonomic behaviors. we provided a complex adaptive system and ob...

Recent discussions in system dynamics have raised questions about the scientific acceptability of system dynamics and impact of system dynamics on social problems. This paper describes two different projects in the area of mental health services research—a research study recognized for its science and a consulting project making an impact on the policy process—and the institutional structures f...

Time is a fundamental dimension in dynamic land-use change modeling. An appropriate treatment of time is essential to realistically simulate landscape dynamics. Current land-use models provide little justification of their treatment of time. As a result, little is known about how the time dimension impacts the spatio-temporal patterns produced by land-use simulation models. This paper reports a...

We study the impact of an intruder on a dense granular material. The process of impact and interaction between the intruder and the granular particles is modeled using discrete element simulations in two spatial dimensions. In the first part of the paper we discuss how the intruder's dynamics depends on (1) the intruder's properties, including its size, shape and composition, (2) the properties...