The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes specific unresponsiveness to donor alloantigens. ...

Introduction Since biologicals antagonize cytokines or receptors involved in the immune system, one could fear that their (long-term) use might affect the quality of the immune system, leading to a defective defense mechanism against infections and tumors, an insufficient response to vaccinations, or a flawed immunoregulation resulting in autoimmunity or autoinflammation. Finally, a biological ...

The skin is the largest bodyorgan and in the normal state, forms a complete anatomic and physiologic barrier between the animal and its environment While providing protection against a variety of noxious physical, chemical, and microbiological agents, it serves as a sensory organ which is in constant communicationwith internal body systemsand reflects pathological processes that may be either p...

In the late 1950's laboratory and clinical evidence suggested that myasthenia gravis was an autoimmune disorder. Since then a voluminous literature has developed documenting the many immunological abnormalities that occur in this condition. Recent findings point to a central disorder of immunoregulation. It is postulated that the disease occurs as a result of host genetic and environmental infl...

The eosinophil cell has been related as a prognostic indicator for cancers. However, its exact function in tumour behaviour is still not clearly defined. In the oral cavity the presence of eosinophils can be a favourable prognostic indicator as well as it may be associated with a poor prognosis. In this short review, we briefly summarize the role of the eosinophils in the general context of imm...

From the ‡Department of Biochemistry, University of Geneva, 30 quai E. Ansermet, 1211 Geneva 4, Switzerland, the §Supra-Biomolecular System Research Group, RIKEN Frontier Research System, Saitama 351-0198, Japan, the ¶Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan, and the Institute for Molecular Bioscience, Centre for Microsco...

From the *Biological Carcinogenesis and Development Program, PRI/DynCorp, Frederick, Maryland 21702-1201; the r of Pathology and the Committee on Immunology, University of Chicago, Chicagg Illinois 60637; the gDepartment of Biology, University of California, San Diego, La Jolla, California 92093; the IIDepartment of Biology and Cancer Center, University of California at Berkeley, Berkeley, Cali...

1 Data Mining and Modelling for Biomedicine group, VIB Inflammation Research Center, Ghent, Belgium 2 Department of Internal Medicine, Ghent University, Ghent, Belgium 3 Center for Medical Genetics, Ghent University, Ghent, Belgium 4 Cancer Research Institute Ghent (CRIG), Ghent, Belgium 5 Laboratory of Immunoregulation, VIB Inflammation Research Center, Ghent, Belgium 6 Bioinformatics Institut...

Dendritic cells (DCs) are the most potent antigen-presenting cells. A strong interest has been developed in DC vaccines for cancer immunotherapy. Besides, angiogenesis is essential for tumor growth. VE-cadherin has a crucial function in various aspects of vascular biological functions. Here, we produced the full VE-cadherin gene modified DC vaccine (DC-VEC). Its antitumor immunity and chief mec...

The surface expression of class II major histocompatibility complex immune-associated (Ia) antigen is a principal accessory function of macrophages for antigen-specific T-cell activation and immunoregulation. To explore the mechanisms of impaired cell-mediated immunity in invasive amebiasis, we investigated the effects of Entamoeba histolytica proteins on gamma interferon (IFN-gamma)-induced Ia...