Stewart, C. J. (1974). Thorax, 29, 252-257. Mushroom worker's lung-two outbreaks. The clinical picture, immunological findings, and working environment of six mushroom farm workers who developed the characteristic features of mushroom worker's lung while handling pasteurized compost are reported and discussed. A specific antigen has not been identified. The sporadic occurrence of the condition ...

Immunological studies of single proteins in a single cell type have been complemented in recent years by larger studies, enabled by emerging high-throughput technologies. This trend has recently been exemplified by the discovery of gene networks controlling regulatory and effector αβ T cell subset development and human hematopoiesis. The Immunological Genome Project (ImmGen) aims to decipher th...

Stable stress-responsive models have been established in murine (Moloney) virus sarcomas, which lend themselves to further study of intervening immunological mechanisms. Maximum tumor size was increased in sex-segregated male BALB/c mice at 6 and 9 months of age and in females subjected to 3 days of electric shock stress following virus inoculation. Reduction in maximum tumor size was found in ...

The cytokine-inducible transcription factors signal transducer and activator of transcription 5A and 5B (STAT5A and STAT5B) are important for the proper development of multicellular eukaryotes. Disturbed signaling cascades evoking uncontrolled expression of STAT5 target genes are associated with cancer and immunological failure. Here, we summarize how STAT5 acetylation is integrated into posttr...

Background Identification of immune biomarkers indicating potential clinical benefit from immunotherapies may contribute to the selection of the right patient for the right therapy. We have recently reported that HLA-DRB1*11 and HLA-A*24 alleles might serve as predictive factors for immunological and clinical responses to vaccination with AE37, the Ii-Key hybrid peptide of HER2776-790 (AE36) in...

INTRODUCTION CD4 T lymphocytes remain the surrogate measure for monitoring HIV progress in resource-limited settings. The absolute CD4 cell counts form the basis for antiretroviral therapy (ART) initiation and monitoring among HIV-infected adults. However, the rate of CD4 cell change differs among patients, and the factors responsible are inadequately documented. OBJECTIVE This study investig...

BACKGROUND Immunological markers (CD4 count) are used in developing countries to decide on initiation of antiretroviral therapy and monitor HIV/AIDS disease progression. HIV is an incurable chronic illness, making quality of life paramount. The direct relationship between quality of life and CD4 count is unclear. The purpose of this study is to determine the relationship between change in CD4 c...

We report here the case of two coworkers infected by same SARS-CoV-2 strain, presenting different immunological outcomes. One patient presented a strong IgG anti-receptor-binding domain immune response correlated with low and rapidly decreasing titer neutralizing antibodies. The other had similar but high antibody titers. Thus, host individual factors may be main drivers varying age clinical se...