نتایج جستجو برای: immunogenic response

تعداد نتایج: 983179  

2017
Anastasia Latanova Stefan Petkov Yulia Kuzmenko Athina Kilpeläinen Alexander Ivanov Olga Smirnova Olga Krotova Sergey Korolev Jorma Hinkula Vadim Karpov Maria Isaguliants Elizaveta Starodubova

Reverse transcriptase (RT) is a key enzyme in viral replication and susceptibility to ART and a crucial target of immunotherapy against drug-resistant HIV-1. RT induces oxidative stress which undermines the attempts to make it immunogenic. We hypothesized that artificial secretion may reduce the stress and make RT more immunogenic. Inactivated multidrug-resistant RT (RT1.14opt-in) was N-termina...

2017
Jingxuan Qiu Tianyi Qiu Yin Huang Zhiwei Cao

Therapeutic antibodies are widely used for disease detection and specific treatments. However, as an exogenous protein, these antibodies can be detected by the human immune system and elicit a response that can lead to serious illnesses. Therapeutic antibodies can be engineered through antibody humanization, which aims to maintain the specificity and biological function of the original antibodi...

Journal: :Infection and immunity 1976
H Y Whang H Mayer M G Schmidt E Neter

Certain polysaccharides have been shown to inhibit the antibody response of rabbits to the common enterobacterial antigen (CA). The present investigation revealed that striking differences exist in the immunosuppressive effects of enteric bacteria and their lipolysaccharides (lps), depending upon CA production by the strains. Mixtures of immunogenic strains (Escherichia coli F2378 [R4], E. coli...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2012
Marie Bénéteau Barbara Zunino Marie A Jacquin Ophélie Meynet Johanna Chiche Ludivine A Pradelli Sandrine Marchetti Aurore Cornille Michel Carles Jean-Ehrland Ricci

Most DNA-damaging agents are weak inducers of an anticancer immune response. Increased glycolysis is one of the best-described hallmarks of tumor cells; therefore, we investigated the impact of glycolysis inhibition, using 2-deoxyglucose (2DG), in combination with cytotoxic agents on the induction of immunogenic cell death. We demonstrated that 2DG synergized with etoposide-induced cytotoxicity...

Journal: :Cancer research 2009
Fei Duan Yun Lin Cailian Liu Manuel E Engelhorn Adam D Cohen Michael Curran Shimon Sakaguchi Taha Merghoub Stephanie Terzulli Jedd D Wolchok Alan N Houghton

How the immune system recognizes and responds to mutations expressed by cancer cells is a critical issue for cancer immunology. Mutated self-polypeptides are particularly strong tumor-specific rejection antigens for natural tumor immunity, but we know remarkably little about T-cell responses to mutated self during tumor growth in vivo, including levels of response, kinetics, and correlates that...

Journal: :Journal of the American Chemical Society 2015
Clancey Wolf Justin B Siegel Christine Tinberg Alessandra Camarca Carmen Gianfrani Shirley Paski Rongjin Guan Gaetano Montelione David Baker Ingrid S Pultz

Celiac disease is characterized by intestinal inflammation triggered by gliadin, a component of dietary gluten. Oral administration of proteases that can rapidly degrade gliadin in the gastric compartment has been proposed as a treatment for celiac disease; however, no protease has been shown to specifically reduce the immunogenic gliadin content, in gastric conditions, to below the threshold s...

Journal: :Infection and immunity 2014
David Montero Paz Orellana Daniela Gutiérrez Daniela Araya Juan Carlos Salazar Valeria Prado Angel Oñate Felipe Del Canto Roberto Vidal

Shiga-toxin producing Escherichia coli (STEC) is the etiologic agent of acute diarrhea, dysentery, and hemolytic-uremic syndrome (HUS). There is no approved vaccine for STEC infection in humans, and antibiotic use is contraindicated, as it promotes Shiga toxin production. In order to identify STEC-associated antigens and immunogenic proteins, outer membrane proteins (OMPs) were extracted from S...

2015
Jie Ji Zhixia Fan Feifan Zhou Xiaojie Wang Lei Shi Haiyan Zhang Peiru Wang Degang Yang Linglin Zhang Wei R. Chen Xiuli Wang

Dendritic cell (DC) based vaccines have emerged as a promising immunotherapy for cancers. However, most DC vaccines so far have achieved only limited success in cancer treatment. Photodynamic therapy (PDT), an established cancer treatment strategy, can cause immunogenic apoptosis to induce an effective antitumor immune response. In this study, we developed a DC-based cancer vaccine using immuno...

2017
Abraham Lin Billy Truong Sohil Patel Nagendra Kaushik Eun Ha Choi Gregory Fridman Alexander Fridman Vandana Miller

A novel application for non-thermal plasma is the induction of immunogenic cancer cell death for cancer immunotherapy. Cells undergoing immunogenic death emit danger signals which facilitate anti-tumor immune responses. Although pathways leading to immunogenic cell death are not fully understood; oxidative stress is considered to be part of the underlying mechanism. Here; we studied the interac...

2013
Niken M. Mahaweni Margaretha E.H. Kaijen-Lambers Jacqueline Dekkers Joachim G.J.V. Aerts Joost P.J.J. Hegmans

BACKGROUND In 2001, it was postulated that tumour-derived exosomes could be a potent source of tumour-associated antigens (TAA). Since then, much knowledge is gained on their role in tumorigenesis but only very recently tumour-derived exosomes were used in dendritic cell (DC)-based immunotherapy. For this, DCs were cultured ex-vivo and loaded with exosomes derived from immunogenic tumours such ...

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