Jean-Paul's research interest is focused on the analysis of the structure and biosynthesis of the cell wall of Aspergillus fumigatus and its interaction with the host. The A. fumigatus genome will now be used to understand multifactorial systems such as fungal virulence of an opportunistic fungus in an immunocompromised host and assembly and regulation of cell wall polymer rearrangement under t...

Toxoplasma gondii is a ubiquitous zoonotic parasite with an obligatory intracellular lifestyle. It relies on specialized set of cytoskeletal and secretory organelles for host cell invasion. When infecting its felid definitive host, T. undergoes sexual reproduction in the intestinal epithelium, producing oocysts that are excreted feces sporulate environment. In other hosts and/or tissues, multip...

Introduction: Cryptococcal meningitis is a rare disorder that is caused by Cryptococcus neoformans in immunocompromised host. CasePresentation: The case was a 64-year-old man with a history of stem cell transplant for acute leukemia, who presented chronic meningitis caused by Cryptococcus neoformans and concurrent neoplastic meningitis with presence of malignant cells only in his cerebrospinal ...

Nocardiosis is an opportunistic, localized or disseminated granulomatous infection caused by an aerobic actinomycete most commonly found in soil, decomposing vegetation, and other organic matter, as well as in fresh and salt water 1. Infection most commonly occurs through the respiratory tract. Manifestations of disease range from cutaneous infection caused by traumatic inoculation of the organ...

Listeria monocytogenes (Lm) is a foodborne bacterial pathogen that causes listeriosis, severe infection manifests as bacteremia and meningo-encephalitis mostly in immunocompromised individuals, maternal–fetal infection. A critical pathogenic determinant of Lm relies on its ability to actively cross the intestinal barrier, disseminate systemically blood–brain placental barriers. Here we illustra...

Introduction: Immunocompromised host has one or more defects in the normal defense mechanisms that protect against infectious agents. Microsporidia are group of protozoa characterized via obligate intracellular and spore formation, detected many hosts. Up till now, 1300 microsporidia species more, related to 150 genera, were, microsporidiosis caused by microsporidia. Objectives: To conduct Mole...

background: encephalitozoon cuniculi infects a wide range of homoeothermic animals, including man. complications due to this microsporidian have been reported only in immunocompromised patients. reports on e. cuniculi in immunocompetent humans are lacking, most probably, because it is not linked to any clinical manifestations in such hosts. the present work was carried out with the aim of study...