Neonatally initiated injection of anti-mu antiserum in mice has been shown to suppress the formation of reaginic antibodies in response to infection with the intestinal nematode, Nippostrongylus brasiliensis. This observation supports the hypothesis that IgE-producing cells arise from IgM-bearing precursors.

A panel of 219 distinct strains of Pseudomonas aeruginosa were serotyped with a set of monoclonal antibodies prepared against the serotype strains of the Homma scheme (J. Y. Homma, Jpn. J. Exp. Med. 46:329-336, 1976). A total of 87.6% were typable, and there was very good agreement with the corresponding polyclonal serotype. A high proportion of strains that were polyagglutinating or nontypable...

1. The sera of 80 per cent of the rabbits intravenously inoculated with fixed amounts of heat-killed pneumococci contained agglutinins and all showed protective antibodies. 2. The sera of 60 per cent of the intraperitoneally inoculated rabbits contained agglutinins and all showed protective antibodies. 3. The sera of 33 per cent of the intramuscularly inoculated rabbits contained agglutinins an...

Immune precipitation followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and densitometry was used to estimate immunoglobulin G antibody levels against the H, P, and M proteins of measles virus in the sera of 24 patients with multiple sclerosis and 24 serologically matched controls. Of the 24 multiple sclerosis sera, 5 showed a statistically significant increase in antibody ti...

BackgroundIgE causes anaphylaxis in type I hypersensitivity diseases by activating degranulation of effector cells such as mast and basophils. The mechanisms that control IgE activity prevent under normal conditions are still enigmatic.ObjectiveWe aimed to unravel how anti-IgE autoantibodies induced we understand their role regulating serum level allergic anaphylaxis.MethodsWe immunized mice wi...

The antigenic character of a filterable agent which induces leukemia in adult mice has been investigated. Mice and rabbits injected with filtrate yielded sera which specifically neutralized infectivity of the agent. Normal sera, sera from mice with other neoplasms-including leukemias from which no causative agent has as yet been obtained,-and sera from leukemic human beings contained no such ne...

Human and swine influenza viruses were regularly neutralized by their homologous immune sera. However, the sera of animals convalescent from infection with either the swine or human influenza virus possessed little, if any, neutralizing capacity for the heterologous virus. Hyperimmunization of animals against swine influenza virus tended to increase the neutralizing capacity of their sera for h...

The effect of unheated guinea pig and human prevaccination serum on the neutralization of vaccinia virus was studied. Enhancement of neutralization was found in all sera containing antibody and was more marked (20- to 150-fold) in sera obtained in the first weeks after primary vaccination than in sera from immune adults or cord sera (4- to 25-fold). The enhancing factor was thought to be comple...

The Sterne live spore vaccine (34F2) is the most widely used veterinary vaccine against anthrax in animals. Antibody responses to several antigens of Bacillus anthracis have been described with a large focus on those against protective antigen (PA). The focus of this study was to evaluate the protective humoral immune response induced by the live spore anthrax vaccine in goats. Boer goats vacci...