Myocardial contractile dysfunction accompanies both systemic and cardiac insults. Septic shock and burn trauma can lead to reversible contractile deficits, whereas ischemia and direct inflammation of the heart can precipitate transient or permanent impairments in contractility. Many of the insults that trigger contractile dysfunction also activate the innate immune system. Activation of the inn...

Inflammatory response comprises endothelial dysfunction and atherosclerotic cascade. Adhesion molecules and cytokines are involved in both injury and reparative processes observed in an inflammed atherosclerotic vascular wall. As markers and mediators of endothelial dysfunction, adhesion molecules and cytokines seem to be a logical target of studying endothelial dysfunction, and especially beca...

Background/aim We aimed to clarify the clinical effect of Korean Red ginseng administered with adjuvant chemotherapy on immune function patients bile duct or pancreatic cancer. Patients and methods This was a prospective, randomized controlled trial conducted at single tertiary center. Twenty-six consecutive who underwent curative resection for cancer followed by 5-fluorouracil/leucovorin gemci...

Various immune response pathways are altered during early, predegenerative stages of glaucoma; however, whether the early immune responses occur secondarily to or independently of neuronal dysfunction is unclear. To investigate this relationship, we used the Wlds allele, which protects from axon dysfunction. We demonstrate that DBA/2J.Wlds mice develop high intraocular pressure (IOP) but are pr...

introduction hydrops fetalis is a serious condition in fetal period, characterized by the presence of serous fluid accumulation in at least two potential spaces in fetus including pleural effusion, pericardial effusion, and ascites. the incidence of hydrops fetalis is one per 2500-3000 pregnancies. this condition is followed by different diseases. fetal hemolytic anemia and its hypoxemia due to...

The pathogenesis of COVID-19 is complicated by immune dysfunction. impact immune-based therapy in patients has been well documented, with some notable studies on the use anti-cytokine medicines. However, complexity disease phenotypes, patient heterogeneity and varying quality evidence from immunotherapy provide problems clinical decision-making. This review seeks to aid therapeutic decision-mak...

Malnutrition, which encompasses under- and overnutrition, is responsible for an enormous morbidity and mortality burden globally. Malnutrition results from disordered nutrient assimilation but is also characterized by recurrent infections and chronic inflammation, implying an underlying immune defect. Defects emerge before birth via modifications in the immunoepigenome of malnourished parents, ...

Inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis cause severe gastrointestinal dysfunction and reduce the quality of life. Despite intensive research, the exact pathogenesis of IBD remains elusive. Mucosal immune responses are central to intestinal homeostasis. Immune responses in the gut are orchestrated through innate and adaptive immune responses. In this pape...