BACKGROUND Intra-articular corticosteroids are a mainstay in the treatment of knee osteoarthritis, and in clinical trials, they demonstrate a large initial analgesic effect that wanes over one to four weeks with the rapid efflux of drug from the joint. The present study was undertaken to determine if FX006, an extended-release formulation of triamcinolone acetonide, can provide pain relief that...

The objective of this study was to determine whether fisheries-related stressors differently influence two populations of adult sockeye salmon (Oncorhynchus nerka) with shared migration timing and location but where one population (i.e., Harrison) spawns 1 mo after the other (i.e., Weaver). Four stressor treatments were used following beach seine capture: (1) immediate release, (2) release afte...

Methods: Two different capsule formulations of these drugs were prepared. Formulation-I contains immediate release uncoated pellets of Rifampicin and Isoniazid. Formulation-IIcontains immediate release pellets of Rifampicin and enteric coated pellets of Isoniazid. These pellets were evaluated for various physicochemical parameters. Enteric coating was mainly done to prevent the release of Isoni...

Introduction: One of the main reasons for the development of the resistance in the therapy for Tuberculosis is the mono drug therapy. This may be due to the drug-drug interactions as the therapy includes combination of various drugs leading to poor bioavailability of these drugs. One such reported interaction is between Rifampicin and Isoniazid which leads to poor bioavailability of Rifampicin....

In mammalian cells, the level of the iron-storage protein ferritin (Ft) is tightly controlled by the iron-regulatory protein-1 (IRP-1) at the posttranscriptional level. This regulation prevents iron acting as a catalyst in reactions between reactive oxygen species and biomolecules. The ultraviolet A (UVA) radiation component of sunlight (320-400 nm) has been shown to be a source of oxidative st...

The aim of this study was to evaluate the feasibility of conducting double-blind controlled randomized clinical trials using twice-a-day immediate-release oral diacetylmorphine (DAM) in heroin-dependent patients, by means of measuring the capacity of oral DAM to block opiate withdrawal and clinicians' ability to distinguish it from morphine and methadone. This was a randomized, phase II, double...

Pills and capsules may release their contents within minutes of ingestion; these are immediate-release formulations. Pills and capsules may also release their contents after a time lag, or a little at a time, or in some other predetermined way; these are time-release formulations. Many drugs in psychiatry have been time-release formulated to reduce their local adverse effects in the gastrointes...