We describe here a novel experimental model of late-phase reaction of immediate hypersensitivity developed in mice. It consists of introducing small fragments of heat-coagulated hen egg white into the subcutaneous tissue of mice. After 14 days, animals challenged with purified ovalbumin into the footpad presented an immediate swelling of the paw peaking at 30 min, followed by two peaks of swell...

One of the recommended first-line treatments for basal cell carcinomas, actinic keratoses and Bowen's disease is photodynamic therapy. Commonly associated side- effects include pain and phototoxicity. Histamine release is a part of this reaction, but whealing urticaria follow noting photodynamic therapy has only been reported by the manufacturer. The aim of this study was to investigate the pre...

Many investigators have demonstrated that a large number of patients who experience anaphylaxis during anesthesia have a history of atopic disease or allergy to a specific substance. Here, we review a hypersensitivity reaction to ketamine in a nine-year-old child with a history of atopic disease.

Allergic reactions to mannitol have been reported rarely, despite its widespread use as a drug and as a food excipient. This is the first case report in which oral mannitol induces an immediate type hypersensitivity as a drug excipient, in a 42 year old man affected by rhinitis to olive tree pollen. Unusual and undervalued risk factors for mannitol hypersensitivity are examined.

Case report An 11 years old boy had history of lip swelling and itching after dental procedure with injection of local anesthetic drug, Articaine (Ubistesin). There was no any skin rash or hives on any parts of the body and no other systemic symptoms. Lip swelling lasted for 2 hours and then spontaneously resolved. The patient was consulted for suspicious allergy to articaine. After thoroughly ...

This is a rare case report of systemic allergic reaction to fish allergen ingested through breast milk. Mother ate raw fish more than 3 times a week. Her consumption of fish was associated with urticaria and wheeze in an infant via breast-feeding. Fish-specific IgE antibodies were detected by skin prick test but not by in vitro IgE test. This case demonstrates that fish protein ingested by moth...

BACKGROUND Despite its clinical effectiveness, allergen immunotherapy (AIT) remains controversial because serious systemic reactions can occur during its administration. Most of the studies on the safety of AIT are retrospective and use different methods, which frequently depart from daily clinical practice. OBJECTIVE The aim of this study was to determine risk factors for adverse reactions, ...

A thymidine analog, 5-ethynyl-2'-deoxyuridine (EdU), has been reported as a rapid labeling tool for direct measurement of cells in S-phase. The alkynyl group of EdU is a biologically inert group that undergoes an extremely selective reaction with azido-functionalized groups via Cu(I)-catalyzed alkyneazide cycloaddition (CuAAC or "click") reaction. Here we report the highly efficient reaction of...

appears on the skin. We separated lymphocytes from the inflamed skin of NC/ Nga mice using collagenase I (Sigma-Aldrich) and counted the numbers of nuocytes (ST21/Sca-11/lineage marker-negative) by FACS. Results: (1) The reactions were hapten specific. Wild-type BALB/c mice showed both immediate and delayed-type reactions, whereas ST2 KO mice did not show any immediate reaction. (2) When IL-33 ...

the anterior maxilla presents a challenging milieu interior for ideal placement of implants because of the compromised bone quality. with the advent of intraoral bone harvesting and augmentation techniques, immediate implant placement into fresh extraction sockets have become more predictable. immediate implant placement has numerous advantages compared to the delayed procedure including superi...