The valued studies of alternative psoriasis treatment options are in a much higher need among the Scientific Community. This study aimed to evaluate anti-psoriatic activity ursolic acid cream imiquimod-induced BALB/c mice. creams containing acid, pentacyclic triterpenoid at percentages 0.1 and 0.2% were formulated. pH, spreadability, physical characteristics acute dermal irritation assessed. An...

Infantile haemangioma is a common childhood condition, which usually resolves spontaneously and is managed expectantly. In a small percentage of complex cases, haemangiomas may be associated with complications such as persistent bleeding, ulceration, feeding difficulties or visual impairment. Active treatment is often necessary in such cases. Current interventions include surgical, laser and im...

Imiquimod, an imidazoquinoline compound, has been widely-recognized for its ability to induce both innate and adaptive immune responses. Topical imiquimod has been approved for the treatment of actinic keratoses (AK), external genital warts (EGW), and superficial basal cell carcinoma (BCC). There are reports of many successful off-label uses as well. The pharmacology and mechanisms of action, s...

Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umb...

CT: computerized tomography OSCC: oral squamous cell carcinoma RMT: retromolar trigone INTRODUCTION Oral squamous cell carcinoma (OSCC) has historically been treated with surgery or radiation with or without chemotherapy, all of which lead to significant posttreatment morbidity. Topical imiquimod cream has been approved by the Food and Drug Administration for treatment of nonhyperkeratotic acti...

In children, lesions caused by the human papillomavirus (HPV) constitute a significant epidemiological issue and a therapeutic dilemma, particularly in the case of anogenital warts. The treatment of anogenital warts in children is a challenge, since standard treatments are generally painful and require the patient to be anesthetized. Imiquimod, a topical immune response modifier, constitutes an...

Basal cell carcinoma (BCC) remains the most common form of nonmelanoma skin cancer (NMSC) in Caucasians, with perhaps as many as 2 million new cases expected to occur in the United States in 2010. Many treatment options, including surgical interventions and nonsurgical alternatives, have been utilized to treat BCC. In this paper, two non-surgical options, imiquimod therapy and photodynamic ther...

Sir—We read with great interest the article by Ramsey and colleagues [1]. In their study, they concluded that imiquimod had no efficacy in controlling Chlamydia trachomatis MoPn (mouse pneumonitis agent) infection in a murine model of female genital tract infection. Imiquimod is an immune response modifier that induces the production of an array of essentially Th1 response promoting cytokines, ...

Desmoplastic trichoepithelioma is a rare benign adnexal tumor. Although it is a benign lesion, patients often want to treat it due to cosmetic concerns when it occurs in an easily visible site. For our two cases, topical 5% imiquimod was an attractive treatment option as it is applied by the patients themselves and it has minimal side effects, including leaving no scar. However, the lesions rec...