We previously developed IM-54 as a novel type of inhibitor of hydrogen-peroxide-induced necrotic cell death. Here, we examined its cell death inhibition profile. IM-54 was found to selectively inhibit oxidative stress-induced necrosis, but it did not inhibit apoptosis induced by various anticancer drugs or Fas ligand, or necroptosis. IM-17, an IM derivative having improved water-solubility and ...

Rapid-acting intramuscular (IM) formulations of atypical antipsychotics offer a significant advance over IM haloperidol in the short-term management of acute schizophrenic episodes. Several short-term open-label randomised studies, typically enrolling two- to three-hundred patients, have compared an atypical antipsychotic with haloperidol. These studies show that IM ziprasidone, IM olanzapine a...

BACKGROUND There have not been any reports in Japan clarifying the efficacy and safety of intramuscular (IM) olanzapine and IM levomepromazine in agitated elderly patients with schizophrenia. This study was a comparative investigation of the clinical efficacy and safety of IM olanzapine and IM levomepromazine in agitated elderly patients with schizophrenia at 2 hours post-dose. METHODS The su...

OBJECTIVES To determine whether any difference exists in responses to indirect moxibustion (IM) relative to thermal stimulation duration. METHODS In experiment 1, 9 subjects attended two experimental sessions consisting of single stimulation with IM or triple stimulation with IM, using a crossover design. A K-type thermocouple temperature probe was fixed on the skin surface at the GV14 acupun...

Atrophic gastritis (AG) and intestinal metaplasia (IM) are the main precursor lesions of gastric cancer as the incidence of gastric cancer increases in the gastric mucosa involved with AG and IM. The prevalence of AG and IM vary depending on countries, even it represents diverse results in the same nation. Usually AG is antecedent of IM but the etiologies of AG and IM are not always the same. T...

Background: The main characteristic of polycystic ovary syndrome (PCOS) is oligomenorrhea with clinical and biochemical signs of hyperandrogenism(HA) and the phenotypic spectrum of PCOS is very broad. There are very limited studies about the features of patients with PCOS in Iran. The purpose of this study is to compare the clinical and laboratory characteristics of PCOS between the overweight ...

Background: Imatinib mesylate (IM), a strong and selective tyrosine kinase inhibitor, has been approved as the front line of treatment in chronic myeloid leukemia (CML) patients. In spite of satisfactory results of imatinib in the treatment of patients with CML, patients with treatment failure or suboptimal response developed resistance that might be because of pharmacogenetic variants. This st...

The latest neuroimaging studies about implicit memory (IM) have revealed that different IM types may be processed by different parts of the brain. However, studies have rarely examined what subtypes of IM processes are affected in patients with various brain injuries. Twenty patients with frontal lobe injury, 25 patients with occipital lobe injury, and 29 healthy controls (HC) were recruited fo...

Während in der Vergangenheit der IT-Einsatz im kaufmännischen Bereich im Vordergrund stand, wird durch die verstärkten Bemühungen zur Kostensenkung, Effizienzund Qualitätssteigerung im Gesundheitswesen auch der medizinische Bereich im Krankenhaus immer stärker von IT-Systemen durchdrungen [1]. Angesichts der Einführung eines pauschalierten Entgeltsystems (DRGs) zum 01.01.2004 für die Abrechnung...

We conceptualize two distinct post-acceptance usage behaviors: (1) routine use (RTN) refers to the use of information system (IS) consistent with normal work processes and (2) innovative use (INV) means users’ applying system features in novel ways. While RTN helps integrate the implemented IS into work processes, INV further extracts the value of the IS. Drawing on motivation theory, we propos...