نتایج جستجو برای: il4
تعداد نتایج: 829 فیلتر نتایج به سال:
چکیده زمینه و هدف : رد حاد کلیه پیوندی یکی از مهمترین عوارض بعد از پیوند کلیه است که تأثیر بسزایی در عملکرد کلیه دارد. این مطالعه با هدف تعیین ارزش پیشگویی سیتوکین های وابسته به th1 و th2 با رد حاد کلیه پیوندی انجام گردید. روش بررسی : در این مطالعه که به صورت مقطعی انجام شد. در 60 بیمار پیوند کلیه که اهدا کننده زنده داشتند، سطح سرمی سیتوکین های وابسته به th1 شامل il2 و ifn g و سیتوکین های و...
BACKGROUND AND AIMS Prosthetic Joint Infection (PJI) is a serious complication of Total Joint Arthroplasty (TJA). The Th-17 immune response characterised by IL (interleukin)-17A, IL-17F, IL-23, chemotactic cytokines and their receptors, plays a prominent role in the immune response to invading bacteria. In addition, high expression of IL-17A has been reported in PJI. The aim of this study was t...
Macrophages are pleiotropic cells capable of performing a broad spectrum of functions. Macrophage phenotypes are classified along a continuum between the extremes of proinflammatory M1 macrophages and anti-inflammatory M2 macrophages. The seemingly opposing functions of M1 and M2 macrophages must be tightly regulated for an effective and proper response to foreign molecules or damaged tissue. E...
Recent studies suggest that pro-inflammatory type M1 macrophages inhibit tumor progression and that anti-inflammatory M2 macrophages enhance it. The aim of this study was to examine the interaction of type M1 and M2 macrophages with pancreatic cancer cells. We studied the migration rate of fluorescein stained pancreatic cancer cells on Matrigel cultured alone or with Granulocyte-Macrophage Colo...
Chromatin modifications, such as reversible histone acetylation, play a key role in the regulation of T cell development and function. However, the role of individual histone deacetylases (HDACs) in T cells is less well understood. In this article, we show by conditional gene targeting that T cell-specific loss of HDAC1 led to an increased inflammatory response in an in vivo allergic airway inf...
OBJECTIVE To investigate whether interleukin 13 (IL13) could act in a chondroprotective manner and protect cartilage stimulated to resorb with a combination of IL1alpha and oncostatin M (OSM), in a similar way to the anti-inflammatory cytokine, IL4. METHODS IL13 was added to explant cultures of bovine nasal cartilage stimulated to resorb with IL1alpha and OSM, and the release of collagen and ...
The present study examined the differential contribution of host genetic background and mycobacterial pathogen variability to biological and mechanistic phenotypes of infection. For this purpose, A/J and C57BL/6J mice were infected intravenously with a low dose of Mycobacterium tuberculosis H37Rv or the Russia, Japan, and Pasteur substrains of Mycobacterium bovis bacille Calmette-Guérin (BCG). ...
BACKGROUND Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μm (PM2.5) and vanadium (V) would be associated with altered buccal cell DNA methylation of targeted asthma genes and decreased lung function among urban children in a nested sub...
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