Indirect-immunofluorescence (IIF) of Human Epithelial-2 (HEp-2) cells is a commonly-used method for the diagnosis of autoimmune diseases. Traditional approach relies on specialists to observe HEp-2 slides via the fluorescence microscope, which suffers from a number of shortcomings like being subjective and labor intensive. In this paper, we proposed a hybrid deep learning network combining the ...

We review the past 25 years of time series research that has been published in journals managed by the International Institute of Forecasters (Journal of Forecasting 1982–1985; International Journal of Forecasting 1985–2005). During this period, over one third of all papers published in these journals concerned time series forecasting. We also review highly influential works on time series fore...

The key problem of cryoablation is that only freezing is often unable to kill the capillaries at tumor edges, leading to a high rate of recurrence. Here, we found that Fe3O4 nanoparticles were highly useful to improve the freezing capability of cryosurgery due to their ability to alter intracellular ice formation (IIF) and growth in tumor cells. The killing efficiency of cryoablation for MCF-7 ...

The insulin/insulin growth factor-1(IGF1)/FOXO (IIF) signal transduction pathway plays a core role in the endocrine system. Although the components of this pathway have been well characterized, the evolutionary pattern remains poorly understood. Here, we perform a comprehensive analysis to study whether the differences of signaling transduction elements exist as well as to determine whether the...

In this paper we address the issue of classifying the fluorescent intensity of a sample in Indirect Immuno-Fluorescence (IIF). Since IIF is a subjective, semi-quantitative test in its very nature, we discuss a strategy to reliably label the image data set by using the diagnoses performed by different physicians. Then, we discuss image pre-processing, feature extraction and selection. Finally, w...

A computing policy is a sequence of rules, where each rule consists of a predicate and a decision, and where each decision is either “accept” or “reject”. A policy P is said to accept (or reject, respectively) a request iif the decision of the first rule in P , that matches the request is “accept” (or “reject”, respectively). Examples of computing policies are firewalls, routing policies and so...

We evaluated the combined use of different fixatives for the identification of atypical perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) in patients with inflammatory bowel diseases (IBD) by indirect immunofluorescence (IIF). Sera from 59 ulcerative colitis (UC) and 37 Crohn's disease (CD) patients, and from 64 healthy controls were studied. The IIF on ethanol-, formalin-, and methan...