Reproducible neurophysiologic testing paradigms are critical for multicenter studies of neuropathy associated with impaired glucose regulation (IGR), yet the best methodologies and endpoints remain to be established. This study evaluates the reproducibility of neurophysiologic tests within a multicenter research setting. Twenty-three participants with neuropathy and IGR were recruited from two ...

Mycobacterium tuberculosis (MTB) acquisition and utilization of nutrients within the host cell is poorly understood, although it has been hypothesized that host lipids probably play an important role in MTB survival. Cholesterol has recently been identified as an important lipid for mycobacterial infection. The mce4 transport system is required for cholesterol import into bacterial cells, and d...

We report on Chandra, NuSTAR, and MDM observations of two INTEGRAL sources, namely IGR J17528-2022 J20063+3641. is an unidentified source, while J20063+3641 was recently identified as a magnetic cataclysmic variable (mCV) by Halpern et al. (2018). The Chandra observation has allowed us to locate the optical counterpart source obtain its spectrum, which shows strong H$\alpha$ emission line. spec...

Here we report on X-ray observations of ten 17-60 keV sources discovered by the INTEGRAL satellite. The primary new information is sub-arcsecond positions obtained Chandra Observatory. In six cases (IGR J17040-4305, IGR J18017-3542, J18112-2641, J18434-0508, J19504+3318, and J20084+3221), a unique counterpart identified with high degree certainty, for five these (all but J19504), Gaia distances...

Aims. We aim to establish the X-ray properties of the intermediate polar candidate IGR J15094–6649 and therefore confirm its inclusion into the class. Methods. 42 856 s of X-ray data from RXTE was analysed. Frequency analysis was used to constrain temporal variations and spectral analysis used to characterise the emission and absorption properties. Results. A spin period of 809.7 ± 0.6 s is pre...

Considering the well established role of nonclassical HLA-G class I molecules in inhibiting natural killer (NK) cell function, the consequence of abnormal HLA-G expression in malignant cells should be the escape of tumors from immunosurveillance. To examine this hypothesis, we analyzed HLA-G expression and NK sensitivity in human malignant melanoma cells. Our analysis of three melanoma cell lin...

The sky region containing the soft gamma-ray repeater SGR 1627–41 and the hard X-ray transient IGR J16358–4726 has been observed with XMM-Newton in September 2004. SGR 1627–41 has been detected with an absorbed flux of ∼9×10 erg cm s (2-10 keV), slightly smaller than that seen with Chandra in 2001-2003. For a distance of 11 kpc, this corresponds to a luminosity of ∼3×10 erg s, the smallest ever...

We present NuSTAR spectral and timing studies of the Supergiant Fast X-ray Transient (SFXT) IGR J17544−2619. The spectrum is well-described by a ∼ 1 keV blackbody and a hard continuum component, as expected from an accreting X-ray pulsar. We detect a cyclotron line at 17 keV, confirming that the compact object in IGR J17544−2619 is indeed a neutron star. This is the first measurement of the mag...