background: this study is performed to reveal most common species and subspecies of leptospires that are main causes of hu­man leptospirosis in guilan, northern province of iran. methods: we performed igm-elisa and mat on 282 blood samples from patients who attended to 3 hospitals in the flat area of guilan province with clinical symptoms consisted with leptospirosis.  all specimens with titers...

b ackground: toxoplasmosis is a serious disease in immunocompromised patients and pregnant women. differentiation of acute and chronic infection is a major challenge in serodiagnosis of the disease. since the aim of this study was to assess the diagnostic utility of recombinant sag1 (rec- sag1) for the detection of toxoplasma -specific igm antibodies in human sera, by an enzyme-linked immunosor...

background leptospirosis as an emerging infectious disease is considered as an important public health problem worldwide. objectives the current study aimed to identify potential risks for leptospirosis among rice farmers in khuzestan province, iran. patients and methods a cross-sectional study was carried out in khuzestan, south west iran, from october to december, 2012. randomly selected part...

As a result of reports received by the Food and Drug Administration (FDA) of false-positive results obtained with FDA-cleared in vitro diagnostic kits for the detection of Toxoplasma-specific human immunoglobulin M (IgM) antibodies, an FDA-sponsored evaluation of six kits was performed. A battery of 258 serum specimens, including 30 specimens drawn 1 to 5 months after initial Toxoplasma infecti...

Acute Toxoplasma gondii infection in early pregnancy carries the risk of transmitting the infection to the fetus with serious sequelae. However, serological testing for IgG/IgM anti-Toxoplasma antibodies may fail to differentiate between a recent and past infection. Two hundred and twenty-four Kuwaiti women in their first trimester were screened for IgG/IgM antibodies by the Vitek Immuno Diagno...

Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease. The etiology and treatment options of IGM remain controversial. Previous case reports have suggested that hyperprolactinemia may be associated with IGM. In the present report, we describe the first case of IGM associated with risperidone-induced hyperprolactinemia.

Secreted IgM was shown to contain truncated mu (mu') chains with an apparent molecular mass of approximately 55 kD. The estimated percentage of IgM heavy (H) chains in the mu' form ranged from less than or equal to 1% in the case of one tumor IgM protein (104E) to greater than or equal to 30% in normal serum IgM. Serum mu' chains lacked antigenic determinants characteristic of immunoglobulin va...

Five meta-analyses and 18 RCTs were considered, including 12 trials studied the effect of IgM in adults [1-12], 5 in newborns [13-17], and one in children 1-24 months old [18]. All interventions were applied with basic therapy (BT). No difference between IgM and albumin was found for adults (Fig.1). However we found significant efficacy of IgM in adults when compared with all comparators, RR 0....