In both human asthmatics and animal models of allergy, allergen-specific IgG can contribute to Th2-mediated allergic inflammation. Mouse models have elucidated an important role for IgG and Fc-gamma receptor (FcγR) signaling on antigen presenting cells (APC) for the induction of airway inflammation. These studies suggest a positive feedback loop between IgG produced by the adaptive B cell respo...

Objectives: A massive immunization program was initiated in France older adults. The aim of the study to assess antibody response following BNT162b2 vaccination nursing home (NH) residents. Methods: Three hundred and sixty-nine NH residents who received two vaccine doses were tested for three weeks after first dose six second dose. We assessed IgG level against SARS-CoV-2 Receptor-Binding Do...

Antiphospholipid antibodies (APLAs) promote inflammatory and procoagulant responses in endothelial cells and monocytes. Previous studies have shown that MyD88, TRAF6, and NF-kappaB mediate cell activation by APLAs. These intermediates are also used by toll-like receptors (TLRs). We investigated the role of TLRs in the cellular response to APLAs. IgGs were isolated from the plasma of 5 patients ...

All children with Mycoplasma pneumoniae infection showed a significant response in IgG immunofluorescent (IMF) antibody titers, which were similar to that of complement-fixing (CF) antibody titers. However, there was a certain degree of variation in IgM IMF antibody response and its persistence. This variation also occurred in cases with pre-existing specific antibodies and good CF and IgG IMF ...

methodology can be used to determine the level of IgG antibodies in serum. Evidence suggests that serum IgG testing may be useful in the early identification of general allergies before IgE antibodies can be detected, although the clinical application of IgG testing remains controversial. The ELISA methodology used to determine food sensitivities generally involves testing for serum levels of I...

Macrophages are less effective than DC at priming naive CD4(+) T cells, suggesting that DC are unique in initiating T cell-dependent Ab responses. We compared the ability of DC and macrophages, pulsed in vitro with Streptococcus pneumoniae, to elicit protein- and polysaccharide-specific Ig isotype production upon adoptive transfer into naive mice. S. pneumoniae-activated DC secreted more proinf...

Tobacco mesophyll protoplasts were previously shown to respond to naphthaleneacetic acid by modifying their transmembrane potential difference. In the present work, evacuolated protoplasts were used to show that this response resides only at the plasmalemma. This electrical response was investigated by using polyclonal antibodies directed against plasma membrane antigens presumably involved in ...