نتایج جستجو برای: ifnγ
تعداد نتایج: 2778 فیلتر نتایج به سال:
مقدمه: فعالیت ورزشی نقش مؤثری در تغییر عوامل مؤثر در سرطان دارد، اما تأثیر فعالیت بدنی بر سطوح عوامل مؤثر سرطان در انسان یا حیوانات مبتلا به آن، تا به حال مورد توجه جدی قرار نگرفته است. پژوهش حاضر به بررسی تأثیر فعالیت ورزشی استقامتی پیوسته بر میزان حجم تومور در موش های مبتلا به سرطان سینه می پردازد. مواد و روش ها: در این مطالعه تعداد 30 سر موش بالب سی ماده (4 تا 5 هفته ای با میانگین وزنی 76/17...
In experiments in non‐inbred rats, it has been established that chronic intoxication of ethanol (30 days, total dose – 6.0 LD50) essentially reduces concentration of cytokines IFNγ, IL‐2, IL‐4, IL‐10 in blood, increases concentration of IL‐6, reduces an interrelation IFNγ/IL‐4 in comparison with the control, suppresses of immune responses, which displays the greater le...
Elevated levels of circulating pro-inflammatory cytokines are associated with symptomology of several psychiatric disorders, notably major depressive disorder. Symptomology has been linked to inflammation/cytokine-dependent induction of the Kynurenine Pathway. Galectins, like pro-inflammatory cytokines, play a role in neuroinflammation and the pathogenesis of several neurological disorders but ...
ELISPOT, ELISA and flow cytometry techniques are often used to study the function of immune system cells. It is tempting to speculate that these assays can be used interchangeably, providing similar information about the cytokine secreting activity of cells: the higher the number of cytokine-positive cells measured by flow cytometry, the higher the number of cytokine-secreting cells expected to...
We have constructed stable virus-like particles displaying the HIV-1 Gag(p17) protein as an N-terminal fusion with an engineered protein domain from the Geobacillus stearothermophilus pyruvate dehydrogenase subunit E2. Mice immunized with the Gag(p17)-E2 60-mer scaffold particles mounted a strong and sustained antibody response. Antibodies directed to Gag(p17) were boosted significantly with ad...
NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor for microbial products. Here, we generated a Nlrp10-/- mouse to delineate the role of NLRP10 in the host immune response and found that Nlrp10-/- dendritic cells (DCs) elicited sub-optimal IFNγ production by antigen-specific CD4+ T cells compared to wild-type (WT) ...
Horizontal transmission of cytomegaloviruses (CMV) occurs via prolonged excretion from mucosal surfaces. We used murine CMV (MCMV) infection to investigate the mechanisms of immune control in secretory organs. CD4 T cells were crucial to cease MCMV replication in the salivary gland (SG) via direct secretion of IFNγ that initiated antiviral signaling on non-hematopoietic cells. In contrast, CD4 ...
Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that PARP9 and PARP14 regulate macrophage activation. In primary macrophages, PARP9 and PARP14 have opposing roles in macrophage activation. PARP14 silencing induces pro-inflammat...
Biomarker studies have shown that expression of the T-cell coregulatory ligand PDL1 on tumor cells correlates with clinical responsiveness to the PD1 antibody nivolumab. Here, we report the findings of a preclinical cancer vaccine study demonstrating vaccine-dependent PDL1 upregulation in the tumor microenvironment. We formulated an IFNγ-inducing cancer vaccine called TEGVAX that combined GM-CS...
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