BACKGROUND Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptors as the basis for LDL lowering by PCSK9 inhibitors, there have been no human studies characterizing the effects of PCSK9 inh...

F or as long as I can remember, an argument has been making the rounds in distributed computing circles about how best to define interfaces for distributed elements. Some advocate the use of an interface definition language (IDL), whereas others prefer to use programming languages directly. (There are even those who prefer to avoid explicitly defining interfaces altogether, but I’ll ignore that...

This study examined the relationships between perfectionism, self-esteem, and will to win effects of gender level achievement on these variables. A total 318 adolescents in age group 12–19 years ( M = 16.10 ± 1.01) completed self-esteem questionnaire, will-to-win perfectionism inventory. Interstate (ISL) athletes obtained higher scores than interdistrict (IDL) following variables: win, four eig...

Nowadays, the complexity of modern telecommunication systems has increased significantly and the requirement for thorough and systematic testing is undisputed. The Testing and Test Control Notation (version 3) (TTCN-3) is an universal and standardised language for the specification and implementation of tests for communication systems. Many systems and in particular object-oriented systems are ...

We have studies the secondary structures of the protein moieties of very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) of human serum by circular dichroism (CD). Two potential complications in the application of this technique to lipoproteins have been evaluated. First, using chronographic potentiometry in CD measurements of VLDL fractions of different mean particl...

Very-fast ultracentrifugation using a benchtop ultracentrifuge was applied to the analysis of lipoproteins in 0.5 ml of human plasma. VLDL, IDL and LDL were flotated at densities of 1.006, 1.019 and 1.063 kg/l in runs lasting 30, 100 and 100 minutes. Chylomicrons, if present, were flotated in a separate run. HDL were isolated by precipitation of the apolipoprotein B-containing lipoproteins from...

Communication software for hand-held devices must be flexible and efficient to deliver the necessary Quality of Service (QoS) to multimedia applications such as real-time audio and video, video on-demand, electronic mail and fax, and Internet telephony. CORBA Object Request Brokers (ORBs) are an emerging middleware standard targeted for distributed applications. The stringent memory constraints...

We have assessed the expression of heterozygosity for lipoprotein lipase (LPL) deficiency by studying a single large French Canadian family comprising 92 persons including 21 carriers of the catalytically defective P207L mutation. Phenotypic changes distinguishing heterozygotes from controls were seen early, before the age of 40 and often before 20 years of age. In the total cohort these change...

Abstract Background To assess the effects of proprotein convertase subtilisin/kexin type 9 inhibitor (evolocumab) on lipoprotein particles subfractions with Nuclear Magnetic Resonance spectroscopy in patients acute coronary syndromes. Methods A total 99 consecutive ACS were enrolled and assigned to either experimental group (n = 54) or control 45). The combination therapy PCSK9 (Repatha®, 140 m...

The effect of the expression of human hepatic lipase (HL) or human apoE on plasma lipoproteins in transgenic rabbits in response to dietary cholesterol was compared with the response of nontransgenic control rabbits. Supplementation of a chow diet with 0.3% cholesterol and 3.0% soybean oil for 10 weeks resulted in markedly increased levels of plasma cholesterol and VLDL and IDL in control rabbi...