background: myelodysplastic syndrome is a mixed clonal disorder of bone marrow progenitor cells. understanding the pattern of the different lineage-specific, immature, and mature markers in myelodysplastic syndrome will help in setting-up the frame of reference to diagnose. patients and methods: we compared 60 bone marrow samples from 30 newly-diagnosed patients with myelodysplastic syndrome an...

Anti-platelet antibody measurement may be important in defining the pathogenesis of thrombocytopenic states. In this paper we compared three anti-human immunoglobulin reagents by using them to detect anti-platelet antibodies on the platelet surface and in the serum of 14 patients with chronic idiopathic thrombocytopenic purpura (ITP) and 22 thrombocytopenic disorders. Samples were analyzed by b...

The treatment of thrombotic thrombo-cytopenic purpura with exchange transfusions, plasma infusions, and plasma exchange. multicenter survey and retrospective analysis of current efficacy of therapeutic plasma exchange. The thrombotic thrombocytopenic purpura and hemolyt-ic uremic syndromes: evaluation, management, and long-term out-et al. ADAMTS13 activity in thrombotic thrombocytopenic purpura...

Results of different types of treatment in 416 adults with chronic idiopathic thrombocytopenic purpura (ITP) were analyzed. Of 368 patients treated with corticosteroids, 278 (77%) achieved complete response (CR ie, normalization of platelet count). However, only 18% of patients had continued complete response (CCR). Results of splenectomy was analyzed in 126 patients, 49% of them achieved CCR a...

In this case report we will describe a rare association between anhyrotic ectodermal dysplasia (AED) and immunodeficiency and autoimmunity [in our case: Idiopathic Thrombocytopenic Purpura (ITP) and Crohn disease]. AED is a rare congenital disorder characterized by sparse hair, abnormal teeth and anhidrosis due to lack of eccrine glands. The survey of 87 cases with (AED) revealed only one Irrit...

Our goal is to set forth our opinion of the best approach to managing adults with primary idiopathic (autoimmune) thrombocytopenic purpura (ITP), with emphasis on the word “opinion.” The paucity of evidence-based medicine on this topic has been noted.1 Both the American Society of Hematology2 and the British Committee for Standards in Haematology General Haematology Task Force3 have issued “pra...

march 2012  25 © 2012 Human Kinetics IJATT 17(2), pp. 25-28 Idiopathic thrombocytopenic purpura (ITP) is a syndrome characterized by a low platelet count in the peripheral blood that is not related to marrow failure.1 ITP is a relatively common syndrome of unknown origin that is increasingly recognized. Approximately 66 adults and 50 children per 1,000,000 are diagnosed with ITP annually.2 The...

High-dose intravenous gammaglobulin (lVlgG) was given to 1 2 children and adults with chronic idiopathic thrombocytopenic purpura (ITP) to avoid splenectomy or because they either failed to respond to or required maintenance with high doses of steroids and/or immunosuppressives. The average platelet count increase to initial therapy was 239.5OO/ zl (range 23.000-790,000). A concomitant lgG Fc r...

High-dose intravenous gammaglobulin (lVlgG) was given to 1 2 children and adults with chronic idiopathic thrombocytopenic purpura (ITP) to avoid splenectomy or because they either failed to respond to or required maintenance with high doses of steroids and/or immunosuppressives. The average platelet count increase to initial therapy was 239.5OO/ zl (range 23.000-790,000). A concomitant lgG Fc r...

common variable immunodeficiency (cvid) is a heterogeneous group of disorders characterized by hypogammaglobulinemia and an increased susceptibility to recurrent infections as well as autoimmunity and malignancies. idiopathic thrombocytopenic purpura (itp) and autoimmune hemolytic anemia (aiha) are two autoimmune disorders which may be seen in association with cvid. among 85 cvid patients, seve...