BACKGROUND Tocilizumab is a humanized monoclonal anti-interleukin-6 (IL-6) receptor antibody and has been approved in Japan for the treatment of Castleman's disease, rheumatoid arthritis (RA), and systemic juvenile idiopathic arthritis. Conjunctivitis and dry eye are known ocular adverse effects, but uveitis has not been reported. CASE REPORT A 72-year-old woman had undergone bilateral catara...

Young girls with a pauciarticular onset of juvenile chronic arthritis and circulating antinuclear antibodies are at risk for chronic uveitis. The actual nuclear antigen for these antinuclear antibodies has not been defined. Conventional laboratory techniques, such as counter immunoelectrophoresis, have shown that antibodies to well defined "extractable nuclear antigens" (eg, RNP, Sm, SS-A, and ...

BACKGROUND The objective of this study was to determine the prevalence of presumed ocular tuberculosis among diagnosed pulmonary tuberculosis patients in a tertiary government hospital in the Philippines and determine its common presentation in the population. This was a cross-sectional study in which 103 patients who were labeled to have active pulmonary tuberculosis underwent history and ocul...

PURPOSE To prospectively study the relationship between Fuchs heterochromic uveitis syndrome (FHUS) and intraocular production of specific antibodies against the rubella virus (RV) in Slovenia. METHODS Using the Goldmann-Witmer coefficient technique, intraocular synthesis of specific antibodies against RV, herpes simplex virus, varicella-zoster virus, cytomegalovirus (CMV) and Toxoplasma gond...

PURPOSE To describe 7 cases of unilateral, chronic and/or recurrent anterior uveitis caused by cytomegalovirus (CMV) in immunocompetent patients; to identify specific ophthalmologic characteristics; and to evaluate the clinical effect of valganciclovir treatment. DESIGN Retrospective observational case series. PARTICIPANTS Immunocompetent patients (n = 7) with a history of chronic and/or re...

Purpose: To review epidemiological aspects of uveitis in Asia and compare it with few major reports from outside of this continent Methods: We have reviewed 522 articles concerning the causes and patterns of uveitis and 22 major epidemiology reviews, registered from 1962 to 2009 in Medline-Database. We have selected 7 major reviews from Asia and compared it with five major articles from Africa,...

Non-infectious uveitis is one of the main and insufficiently studied causes disability blindness in patients with immuno-inflammatory diseases. Uveitis associated spondyloarthritis, Behcet’s disease, juvenile idiopathic arthritis, systemic sarcoidosis Vogt-Koyanagi-Harada syndrome are described more often better than others, but pathogenesis different variants their course not well understood. ...

PurposeTo assess the long-term outcome of uveitis in juvenile idiopathic arthritis (JIA).DesignPopulation-based, multicenter, prospective JIA cohort, with a cross-sectional assessment JIA-associated (JIA-U) 18 years after onset JIA.ParticipantsA total 434 patients JIA, whom 96 had uveitis, from defined geographic areas Denmark, Finland, Norway, and Sweden.MethodsPatients between January 1997 Ju...

To determine whether complement is activated in uveitis we have measured plasma levels of C3d, a sensitive indicator of complement activation. Increased levels of C3d were found in 11 of 15 patients with idiopathic uveitis, 13 of whom had circulating immune complexes containing complement components. Since during complement activation potent mediators of inflammation are generated, it is sugges...

Infectious uveitis is a significant cause of blindness in South Africa, especially among HIV-infected individuals. The visual outcome of uveitis depends on early clinical and laboratory diagnosis to guide therapeutic intervention. Analyses of aqueous humor, obtained by anterior chamber paracentesis, directs the differential diagnosis in infectious uveitis. However, although safe and potentially...