The European S3 guidelines on the systemic treatment of psoriasis1 and the British Association of Dermatologists’ guidelines for biologic interventions for psoriasis2 were published shortly after the Spanish guidelines, whose coauthors included the authors of this article.3 Without entering into an exhaustive discussion of the transcription or even conceptual errors that may be found in any pub...

OBJECTIVE Moyamoya disease (MMD) is an intracranial steno-occlusive pathology characterized by progressive narrowing of proximal large vessels, including the terminal internal carotid arteries (ICAs), middle cerebral arteries, or anterior arteries. Named for “puff smoke” appearance anomalous vascularization visualized on angiography, MMD lacks a well-defined etiology, although significant insig...

An efficient multi-block Newton–Krylov algorithm using the compressible Navier–Stokes equations is presented for the analysis and design of high-lift airfoil configurations. The preconditioned generalized minimum residual (GMRES) method is applied to solve the discreteadjoint equation, leading to a fast computation of accurate objective function gradients. Furthermore, the GMRES method is used ...

A 6‐year‐old female presented with sudden‐onset right‐sided hemiparesis with motor aphasia for the past 7 days. Magnetic resonance imaging of the brain [Figure 1a] revealed acute infarct in the left parietooccipital region. Magnetic resonance angiogram (MRA) [Figure 1b] and computed tomography angiogram (CTA) [Figure 2] showed narrowing of bilateral supraclinoid internal carotid arteries (ICAs)...

A general multi-step approach for setting up, solving and solution analysis of computer aided molecular design (CAMD) problems is presented. The approach differs from previous work within the field of CAMD since it also addresses the need for a computer aided problem formulation and result analysis. The problem formulation step incorporates a knowledge base for the identification and setup of t...

S. T. Cundiff,1 B. C. Collings,2,3 N. N. Akhmediev,4 J. M. Soto-Crespo,5 K. Bergman,2 and W. H. Knox3 1JILA, University of Colorado and National Institute of Standards and Technology, Boulder, Colorado 80309-0440 2Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544 3Bell Labs, Lucent Technologies, Holmdel, New Jersey 07733 4Australian Photonics Cooperative Re...

BACKGROUND AND PURPOSE Reteplase (RP) and urokinase (UK) are being used "off-label" to treat acute ischemic stroke. The safety and efficacy of intra-arterial RP or UK in the treatment of acute ischemic stroke, however, has yet to be proved. We aim to evaluate the safety and efficacy of RP compared with UK in acute ischemic stroke patients with large vessel occlusion. METHODS Retrospective ana...

BACKGROUND AND PURPOSE Internal carotid artery (ICA) atheromatous disease is an important cause of ischemic stroke, and endarterectomy or stent placement is typically indicated for symptomatic patients with > or = 70% stenosis. Our purpose was to compare contrast-enhanced MR angiography (CE-MRA) with unenhanced 2D time-of-flight MR angiography (2D TOF MRA) in detecting hemodynamically significa...