cells (HUVECs). Methods and Results—ApoE / mice were treated with sodium hydrosulfide (NaHS) or DL-propargylglycine (PPG); HUVECs were pretreated with NaHS. Compared with control mice, apoE / mice showed decreased plasma H2S level and aortic H2S production but increased plasma ICAM-1 and aortic ICAM-1 protein and mRNA. Compared with apoE / mice, apoE / NaHS mice showed increased plasma H2S leve...

BACKGROUND We reported an increase in serum lipoprotein(a) [Lp(a)] levels in patients with thromboangiitis obliterans, suggesting that Lp(a) could also contribute to the pathogenesis of cardiovascular diseases by a mechanism different from atherosclerosis. Adhesion molecules were shown to contribute to the development of not only atherosclerotic but also inflammatory vascular diseases. METHOD...

Targeting of drug nanocarriers (NCs) to intercellular adhesion molecule-1 (ICAM-1), an endothelial-surface protein overexpressed in many pathologies, has shown promise for therapeutic delivery into and across this lining. Yet, due to the role of ICAM-1 in inflammation, the effects of targeting this receptor need investigation. Since ICAM-1 binding by natural ligands (leukocyte integrins) result...

Introduction: The prevalence of metabolic syndrome (MetS) in Indonesia is 39% and it higher females than males (46% vs. 28%). Features this comprise low-grade chronic inflammation endothelial dysfunction from cardiometabolic abnormalities. High-sensitive C-reactive protein (HsCRP) a biomarker cardiovascular disease, whereas ferritin pentraxin-3 (PTX-3) are markers inflammation. One the an inter...

Immunological explanatory approaches are becoming increasingly important in schizophrenia research. In this context, the function of blood-brain barrier (BBB) and blood-cerebrospinal fluid (CSF) (BCSFB) plays an essential role. Different adhesion molecules, such as intercellular molecule-1 (ICAM-1) vascular cell (VCAM-1), key elements sustaining integrity BBB BCSFB. The objectives study were to...

BACKGROUND Intercellular adhesion molecule 1 (ICAM-1) is an immunoglobulin-like cell adhesion molecule expressed on the surface of multiple cell types, including airway epithelial cells. It has been documented that cross-linking ICAM-1 on the surface of leukocytes results in changes in cellular function through outside-inside signaling; however, the effect of cross-linking ICAM-1 on the surface...

Abstract Background and Aims Chronic kidney disease (CKD) is associated with cardiovascular (CVD). CVD in turn related to endothelial dysfunction, degradation of the glycocalyx (EG), releasing its components into bloodstream. The EG consists glycosaminoglycans proteoglycans, such as Perlecan. aim study analyse levels perlecan plasma different stages CKD, relate them age inflammatory monocytes, ...

Alopecia areata (AA) is caused by T cell-mediated autoimmune attack of the hair follicle. Therefore, inhibition lymphocyte migration and pathogenic activity represents an attractive therapeutic approach in treatment lymphocyte-mediated diseases, including AA. The function antigen-1 (LFA-1) receptor signaling pathway plays a crucial role cell activation, cells to target tissues formation classic...

In this study, we investigated the involvement of Th1 cytokines in the expression of cell adhesion molecules (CAM) and recruitment of inflammatory cells to the heart of mice infected with Trypanosoma cruzi. Our results show that endogenously produced IFN-gamma is essential to induce optimal expression of VCAM-1 and ICAM-1 on the cardiac vascular endothelium of infected mice. Furthermore, the in...

The first domain of intercellular adhesion molecule-1 (ICAM-1) binds to the leucocyte function-associated antigen-1 (LFA-1) I domain, which contains the principal ligand-binding site of this leucocyte integrin. Whether the function of the second domain is also to directly bind LFA-1 has been unclear. Our data show that mutation in the hydrophilic EF loop of ICAM-1 domain 2 resulted in impaired ...