?emsüddin es-Semerkandî mant?k, matematik, astronomi, mübâhase, felsefe ve kelam alanlar?nda yazd??? eserler ile kendisini aklî naklî ilimlerde kan?tlam?? önemli bir Türk-?slam âlimidir. Karakteristik problemlerde benimsedi?i görü?leriyle Hanefî-Mâturîdî kimli?ini ön plana ç?karan Semerkandî, gelenek içerisinde felsefî kelâm yöntemini benimseyen ilk âlim olarak temâyüz etmektedir. Cevher-araz h...

Case based reasoning (CBR) methodology presents a foundation for a new technology of building intelligent computeraided diagnoses systems. This Technology directly addresses the problems found in the traditional Artificial Intelligence (AI) techniques, e.g. the problems of knowledge acquisition, remembering, robust and maintenance. This paper discusses the CBR methodology, the research issues a...

BACKGROUND The Fisher 344 (F344) rat kidney transplanted to a Lewis rat recipient is a common model of chronic renal allograft nephropathy (CAN); however, CAN does not develop when the Lewis kidney is grafted into a F344 recipient. In this study we investigated whether a difference in nephron number/glomerular volume exists between the strains that could contribute to a greater susceptibility t...

Septic shock is a common condition carrying a high mortality. The clinical features are a high cardiac output circulation with hypotension and vascular hyporeactivity and evidence of organ failure. I developed an organ culture in vitro model and a fluid-resuscitated in vivo model of sepsis to investigate potential underlying mechanisms for the vascular hyporeactivity, namely inducible nitric ox...

This paper presents a new variable step-size normalized subband adaptive filter (VSS-NSAF) algorithm. In the proposed VSS-NSAF, the step-size changes in order to have largest decrease in the mean square deviation (MSD) for sequential iterations. To reduce the computational complexity of VSS-NSAF, the variable step-size selective partial update normalized subband adaptive filter (VSS-SPU-NSAF) i...

This prospective follow-up study was designed to analyze the causes and outcome of upper gastrointestinal bleeding among patients presenting by hematemesis and/or melena to Emergency Endoscopy Unit, Ain Shams University Hospitals. One thousand patients presented by upper GIT bleeding were subjected to complete clinical evaluation, emergency upper gastrointestinal endoscopy and therapeutic inter...

AIMS While a wealth of data has uncovered distinct microRNA (miR) expression alterations in hypertrophic and ischaemic/reperfused (I/R) hearts, little is known about miR regulation and response to ischaemic preconditioning (IPC). METHODS AND RESULTS We analysed miRs in murine hearts preconditioned with six cycles of 4 min ischaemia via coronary artery occlusion, followed by 4 min reperfusion ...

Background: Hypovolemic shock is a clinical syndrome of inadequate tissue perfusion; it results in decreased supply oxygen and nutrients to cells leading widespread cellular necrosis, multiple organ dysfunction failure then death. The importance educational guidelines for nurses are descriptions what nurses expected know be able do at specific stage their work on patients with hypovolem...

Mitochondrial dysfunction and increased mito-ROS emission are hallmarks of heart failure (HF) cardiac hypertrophy. Assembly electron transport chain (ETC) elements into large respiratory supercomplexes may ensure high efficiency transport, defects in supercomplex formation can increase mito-ROS. However, potential changes ETC their roles pathophysiology HF or hypertrophy yet to be uncovered. Us...