background: gemcitabine (2′, 2′-difluoro-2′- deoxycytidine, an analogue of deoxycytidine) is a relatively new drug with wide range of anti-cancer activity. in this study, radiosensitizing effects of gemcitabine was investigated on hela and mrc5 human originated cell lines under both chronically hypoxic and normoxic conditions using the micronucleus (mn) assay. materials and methods: for inducti...

Twenty-one patients with various forms of myoclonus are presented. Phenacemide was given to five patients with considerable benefit to three, but with serious toxic effects in two. Another acetylurea derivative, pheneturide, was given to 19 patients and was well tolerated. Myoclonus was completely or substantially controlled in 12 patients.

BACKGROUND Familial adult myoclonic epilepsy (FAME) is an autosomal dominant syndrome characterized by a core triad of cortical tremor, multifocal myoclonus, and generalized tonic-clonic seizures. OBJECTIVES To expand the phenotypic spectrum of FAME, to highlight diagnostic pointers to this underrecognized disorder, and to refine the FAME2 genetic locus. DESIGN Observational family study. ...

Introduction. Myoclonus status epilepticus is independently associated with poor outcome in coma patients after cardiac arrest. Determining if myoclonus is of cortical origin on continuous electroencephalography (CEEG) can be difficult secondary to the muscle artifact obscuring the underlying CEEG. The use of a neuromuscular blocker can be useful in these cases. Methods. Retrospective review of...

Background: Etomidate is one of the popular rapidly acting inducing agents with cardio-stable profile but associated side effects such as myoclonus. Myoclonus can lead to regurgitation, prolapse vitreous in open globe or many other complications. Aims and Objectives: The objectives are follows: To compare efficacy Fentanyl midazolam for prevention induced study hemodynamic parameters fentanyl p...

Tonic and clonic muscle spasm of the lower extremities and trunk is a well-known complication of myelography [1, 2] and accidental subdural injection of contrast material [3]. Occasionally , myoclonus also appears after aortography. It is postulated that some of the contrast medium reaches the spinal column through intercostal , lumbar, and lumbosacral segmental arteries. The risk is higher in ...

Here we report a patient who suffered an acute infarction of the contralateral postcentral cerebral cortex and subsequently developed unilateral partial epilepsy with negative myoclonus. The findings of brain magnetic resonance imaging, polygraphic recordings of the postcentral somatosensory area, and response to anticonvulsant treatment support the presence of a cause-and-effect relationship, ...

Myoclonus is an extremely rare perioperative complication following neuraxial anesthesia. It has also been reported to occur due to peripheral nerve lesions. We report a case of self-limiting myoclonus following a routine peripheral nerve block in an otherwise healthy patient.