BACKGROUND AND PURPOSE This study was undertaken to determine whether the initial component of the classical complement (C) activation pathway contributes to hypoxic-ischemic brain injury in neonatal mice. METHODS Hypoxia-ischemia (HI) was produced in C1q(-/-) and wild-type (WT) neonatal mice. At 24 hours after HI, neonatal mouse reflex performance and cerebral infarct volume were assessed. L...

patients and methods the study was performed on 40 tbi patients referred to the shahid beheshti hospital of kashan city and 40 normal controls in kashan. traumatic brain injured patients and normal controls were selected by convenience sampling. two groups filled out the demographic sheet, cognitive failures questionnaire (cfq) and meta-cognitions questionnaire 30 (mcq-30). the data were analyz...

Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed protein kinase, which regulates cell fate in numerous injury conditions. Therefore, ASK1 may be a promising novel therapeutic target for injury. However, the expression and distribution of ASK1 in the perinatal brain following hypoxia-ischemia (HI) remains to be elucidated. In the present study, western blotting and immunof...

Injury to the fragile immature brain is implicated in the manifestation of long-term neurological disorders, including childhood disability such as cerebral palsy, learning disability and behavioral disorders. Advancements in perinatal practice and improved care mean the majority of infants suffering from perinatal brain injury will survive, with many subtle clinical symptoms going undiagnosed ...

There is an increase in the numbers of neural precursors in the SVZ (subventricular zone) after moderate ischaemic injuries, but the extent of stem cell expansion and the resultant cell regeneration is modest. Therefore our studies have focused on understanding the signals that regulate these processes towards achieving a more robust amplification of the stem/progenitor cell pool. The goal of t...

J. T. Kim, K. H. Lim, H. J. Cho, J. H. Lee, K. S. Kim University of Ulsan College of Medicine, seoul, Korea, Republic of, Asan Institute for Life Sciences, seoul, Korea, Republic of, Sungkyunkwan University School of Medicine, seoul, Korea, Republic of Purpose It is well known that apoptosis is a major pathophysiology of hypoxic-ischemic brain injury in newborn rats [1]. Calcium influx to intra...

The nine months of intrauterine life are a continuum during which a series of situations and events can occur that result in abnormalities of normal brain growth or injury to the developing brain of the fetus. Genetic mutations and hereditary syndromes can predispose the fetus to intrauterine death, mortality in early life, and various degrees and combinations of brain injury and neurological d...

OBJECTIVE To examine whether neonatal seizures are associated with neurodevelopmental outcomes in infants with hypoxia-ischemia independent of the presence and severity of brain injury seen on magnetic resonance imaging (MRI). STUDY DESIGN We used multivariate regression to examine the independent effect of clinical neonatal seizures and their treatment on neurodevelopment in 77 term newborns...

Cohort studies have demonstrated a higher vulnerability in males towards ischemic and/or hypoxic-ischemic injury in infants born near- or full-term. Male sex was also associated with limited brain repair following neonatal stroke and hypoxia-ischemia, leading to increased incidence of long-term cognitive deficits compared to females with similar brain injury. As a result, the design of pre-clin...