ABSTRACT The metabolic index concept combines data and known thermal sensitivities to estimate the factorial aerobic scope of animals in different habitats, which is valuable for understanding demands that constrain species' geographical distributions. An important assumption this O2 supply capacity (which equivalent rate oxygen consumption divided by environmental partial pressure oxygen: ) co...

Hypoxia is an important stress for organisms, including plants and mammals. In plants, hypoxia can be the consequence of flooding causes crop losses worldwide. mammals, may result pathological conditions. Understanding regulation responses to offers insights into novel approaches improvement, particularly development flooding-tolerant crops producing better therapeutics hypoxia-related diseases...

We hypothesized that, in male rats, 10% fructose in drinking water would depress ventilatory responsiveness to acute hypoxia (10% O2 in N2) and hypercapnia (5% CO2 in O2) that would be depressed further by exposure to intermittent hypoxia. Minute ventilation (Ve) in air and in response to acute hypoxia and hypercapnia was evaluated in 10 rats before fructose feeding (FF), during 6 wk of FF, and...

Hepatocellular carcinoma is one of the most prevalent and lethal cancers with limited therapeutic options. Pathogenesis of this disease involves tumor hypoxia and the activation of hypoxia inducible factors. In this review, we describe the current understanding of hypoxia signaling pathway and summarize the expression, function and target genes of hypoxia inducible factors in hepatocellular car...

CONTEXT Exposure of hepatocytes to pathological conditions in a microenvironment of hypoxia and reoxygenation is very frequent in hepatic diseases. Several substances present perspectives for cytoprotective action on hepatocyte submitted to reoxygenation after hypoxia and simple hypoxia. OBJECTIVE We research therapeutic options for hepatocytes submitted to hypoxia and hypoxia + reoxygenation...

Connective tissue growth factor (CTGF) is known to be a profibrotic growth factor, which mediate the fibrotic effect of transforming growth factor-beta (TGF-beta) and to stimulate cell proliferation and matrix production. CTGF has been shown to be hypoxia-inducible in several cell types. Here we investigated the effect of hypoxia on CTGF gene expression in cultured mouse renal tubular cells (MT...

BACKGROUND AND PURPOSE Hypoxia in tumours is known to cause resistance to conventional chemotherapeutic drugs. In contrast, little is known about the effects of hypoxia on targeted anti-cancer drugs. This study evaluated the effect of hypoxia on a series of clinically approved tyrosine kinase inhibitors (TKIs). EXPERIMENTAL APPROACH The effect of hypoxia (0.1% oxygen) on the activity of conve...

Degenerate shoulder tendons display evidence of hypoxia. However tendons are relatively avascular and not considered to have high oxygen requirements and the vulnerability of tendon cells to hypoxia is unclear. Cultured human tenocytes were exposed to hypoxia and the cellular response detected using QPCR, Western blotting, viability, and ELISA assays. We find that tenocytes respond to hypoxia i...