BACKGROUND Hyperinsulinism in childhood is often caused by genetic defects involving the regulation of insulin secretion leading to recurrent episodes of hypoglycaemia. We report two patients with exercise induced hypoglycaemia. METHODS Standardised short exercise tests with frequent blood glucose and plasma insulin measurements were performed in the patients and young healthy controls. RES...

Dumping syndrome is a commonly recognized complication after gastric and oesophageal surgery. It is characterized by postprandial early gastrointestinal and vasomotor symptoms followed by late hypoglycaemia. Early dumping symptoms include abdominal pain, bloating, nausea, vomiting, flushing, tachycardia and hypotension. Late dumping symptoms which occur 1–3 h after food are thought to be due to...

For glucose-lowering drugs inducing hypoglycemia, a marginally protective effect on the risk of MACE was observed for HbA1c 48-58 mmol/mol, whereas significant reduction microvascular complications HbA1c<49 but with higher severe hypoglycaemia. Drugs not hypoglycaemia were associated MACE, renal adverse events, and all-cause mortality, HbA1c<7% (no data lower targets). Conclusions: presen...

Twenty nine (1.8%) of a national cohort of 1600 patients with growth hormone deficiency presented before the age of 2 years. Sixteen of the 29 presented before 6 months of age--11 with symptomatic hypoglycaemia, four with failure to thrive, and one with obesity. Hypoglycaemia was persistent and difficult to control until growth hormone treatment was started. Ten of the 11 hypoglycaemic patients...

AIM To determine if children born to mothers with diabetes mellitus during pregnancy, who subsequently developed neonatal hypoglycaemia, experienced long-term neurological dysfunction. METHODS Thirteen children with, and 15 without, neonatal hypoglycaemia (blood glucose < 1.5 mmol/l) were randomly selected from a larger cohort and investigated at the age of 8 years. They were also compared wi...

We report here development of hypoglycaemia in the convalescent phase of Japanese encephalitis virus (JEV) infection in mice by the induction of antigen-specific Ly1- 2+ T cells in the spleen which mediate hypoglycaemia through the generation of soluble T cell hypoglycaemic factor (TCHF). The TCHF acted in a dose-dependent manner and was found to be trypsin-sensitive and thermolabile. It was pu...

Habbick, B. F., McNeish, A. S., and Stephenson, J. B. P. (1971). Archives of Disease in Childhood, 46, 295. Diagnosis of ketotic hypoglycaemia of childhood. Twenty cases of ketotic hypoglycaemia have been diagnosed in one medical unit in the past 8 years. Typically the children were 'dysmature' at birth, with a history suggesting hypoglycaemia in the first 36 hours of life, and they have remain...

Infusion of 67 g ethanol over four hours in fasted, non-obese normal men (a) induced hypoglycaemia by inhibiting gluconeogenesis; (b) produced noticeable increases in blood lactate, 3-hydroxybutyrate, and free fatty acid concentrations; (c) depressed plasma growth hormone concentrations, despite hypoglycaemia; and (d) raised plasma cortisol concentrations before significant hypoglycaemia occurr...