Bronchiolitis is a common disorder in young children that often results in hospitalisation. Except for a possible effect of nebulised hypertonic saline (sodium chloride), no evidence-based therapy is available. This study investigated the efficacy of nebulised 3% and 6% hypertonic saline compared with 0.9% hypertonic saline in children hospitalised with viral bronchiolitis. In this multicentre,...

We have measured the airway responses to methacholine on three days in sixteen non-asthmatic subjects. On the first day the methacholine challenge alone was performed. The other two days were randomized between pretreatment with distilled water or hypertonic saline administered by ultrasonic nebulizer. Distilled water and hypertonic saline did not affect baseline specific conductance (sGaw). Pr...

Dahl showed that feeding KCl prevents the rise in blood pressure caused by a high NaCl diet in salt-sensitive Dahl "S" rats. Such S rats when normotensive on a low NaCl diet have a 2 to 3 times greater pressor response than Dahl "R" rats to intracerebroventricular hypertonic saline (600 mOsm/liter) or angiotensin II (AII) (500 ng). Does dietary KCl prevent NaCl hypertension in S rats partly by ...

OBJECTIVE To evaluate the predictability and safety of hypertonic saline (5% sodium chloride) [correction]-assisted laser-assisted subepithelial keratectomy (HS-LASEK) vs 20% alcohol-assisted LASEK (A-LASEK). SETTING American Laser Medical Center, Rishon Le-Zion, Israel. METHODS Fifty-two consecutive eyes (26 patients) were randomized to HS-LASEK (30 eyes) and A-LASEK (22 eyes) groups. The ...

The hypertonic saline test is a useful technique for distinguishing partial diabetes insipidus from psychogenic polydipsia, and for the diagnosis of complex disorders of osmoreceptor and posterior pituitary function. However, there is little information concerning its use in childhood. The experience of using this test in five children (11 months to 18 years) who presented diagnostic problems i...

Conventional resuscitation of traumatic hemorrhagic shock involves the intravenous administration of isotonic (normal saline) or slightly hypotonic (lactated Ringer’s, LR) solution beginning in the prehospital setting. Although not conclusive, prior animal and human studies have suggested that alternative resuscitation with hypertonic saline (7.5%) solutions may reduce mortality in these patien...

Introduction The pathogenesis of AKI is characterized by a deterioration in tissue perfusion and oxygenation in combination with inflammation resulting in renal microcirculatory dysfunction and kidney failure. Hypertonic saline (HS) solution increases serum osmolarity which results in an redistribution of fluid from the interstitial and intracellular spaces to the intravascular space potentiall...

Background: One of the most serious late complications, after evacuation of liver hydatid cyst and instillation of scolicidal agents is sclerosing cholangitis, most probably caused by the type of scolicidal agents instilled. Objective:  To determine the incidence of sclerosing cholangitis after intra-biliary tract infusion of 5% saline and 0.5% silver nitrate. Methods: 5% hypertonic saline and ...

The present review discusses the hemodynamic effects of hypertonic saline in experimental shock and in patients with sepsis. We comment on the mechanisms of action of hypertonic saline, calling upon data in hemorrhagic and septic shock. Specific actions of hypertonic saline in severe sepsis and septic shock are highlighted. Data are available that support potential benefits of hypertonic saline...

OBJECTIVE Widespread deep tissue pain hyperalgesia was evaluated in women with chronic whiplash associated disorder (n = 25) and controls (n = 10) using computerized cuff pressure algometry and hypertonic saline infusion. METHODS A pneumatic double-chamber cuff was placed around: (i) the arm and (ii) the leg. Cuff inflation rate was constant and the pain intensity was registered continuously ...