Offspring born to mothers with hypertensive pregnancy have higher childhood blood pressure. We hypothesized this relates to prenatally programmed differences in the underlying vascular pathophysiology of the offspring and that these would be most apparent in those born preterm because of severe hypertension. We carried out a 20-year follow-up study of 71 subjects born preterm, 19 to a hypertens...

Hypertensive disorders of pregnancy (HDP) complicate approximately 10% pregnancies. In addition to multiorgan manifestations related endothelial dysfunction, HDP confers an increased risk cardiovascular disease during delivery hospitalisation, such as heart failure, pulmonary oedema, acute MI and cerebrovascular events. However, the legacy extends beyond birth since these women are significantl...

Preeclampsia is a hypertensive, proteinuric disease that affects 5-10% of all pregnancies and is a leading cause of maternal and perinatal morbidity/mortality (Soto et al., J Matern Fetal Neonatal Med 25: 498-507, 2011). The primary treatment for preeclampsia still is delivery of the fetus and placenta. The underlying mechanisms remain elusive. One possibility is inadequate uterine angiogenesis...

Hypertension during pregnancy is a risk factor for many complications both for the mother and fetus and may lead to mortality of both due to serious complications. Nearly 8% of pregnancies are complicated by hypertensive disorders. Active management of hypertension is necessary to reduce complications of hypertension in pregnancy. Drugs like labetalol, methyldopa are most commonly used oral dru...

Preeclampsia is a hypertensive disorder that occurs during pregnancy. It has an unknown etiology and affects approximately 5-8% of pregnancies worldwide. The pathophysiology of preeclampsia is not yet known, and preeclampsia has been called "a disease of theories." The central symptom of preeclampsia is hypertension. However, the etiology of the hypertension is unknown. In this review, we analy...

Here in we are reporting a 35-year-old pregnant, hypertensive woman with a strict descending aorta coarctation. She had two missing pregnancies which were complicated with hypertension, but which were not diagnosed for any pathologies before. We diagnosed coarctation of aorta, but however postponed her treatment after delivery of baby, because hypertension was under control with medical treatme...

Correspondence to: Dr Catherine Nelson-Piercy, Department of Obstetrics, Guys and St Thomas’ Hospitals, North Wing, St Thomas’ Hospital, Lambeth Palace Road, London SE1 7EH, UK; catherine.nelson-piercy@ gstt.sthames.nhs.uk _________________________ H ypertension is the most common medical problem encountered in pregnancy and remains an important cause of maternal, and fetal, morbidity and morta...

OBJECTIVE To relate anticoagulant use to pregnancy complications in women with systemic lupus erythematosus (SLE) and primary antiphospholipid syndrome (APS). METHODS All ongoing pregnancies, 184, in two Dutch tertiary centers between 2000 and 2015. RESULTS LMWH and aspirin was prescribed in 15/109 SLE women without antiphospholipid antibodies (aPL), 5/14 with aPL, 11/13 with APS, 45/48 wit...

In order to evaluate blood pressure and heart rate variability as a potent diagnostic tool for different hypertensive pregnancy disorders we started a clinical trial recording these variables in early pregnancies predisposed for preeclampsia. During routine measurements one of the patients experienced a grand mal epileptic seizure. Since the parameters of both heart rate and blood pressure vari...

Preeclampsia is one of the most commonly encountered hypertensive disorders of pregnancy (HDP). It is mostly feared because of its serious maternal and fetal mortalities and morbidities. Ten percent of women have high blood pressure (BP) during pregnancy, and preeclampsia complicates 2% to 8% of pregnancies 1 . Overall, 10% to 15% of direct maternal deaths are associated with preeclampsia and e...