نتایج جستجو برای: hyperpolarization activiated current if sino atrial node
تعداد نتایج: 1634876 فیلتر نتایج به سال:
Postoperative rhythm disorders are a serious complication of coronary surgery and they are associated with increased morbidity and mortality. Atrial fibrillation is the most common complication after cardiac surgery, with an incidence of 30% after coronary artery bypass grafting (Camm et al.,2010). There are few data about the etiology of atrial fibrillation in this setting, factors such as int...
The sinoatrial node (SAN) contains a small number of pacemaker cells (PCs), specialized cardiomyocytes whose automatic firing triggers each heart beat. Autonomic and endocrine modulation of PC automaticity enables precise neurohormonal regulation of heart rate (HR) in accordance with physiological demand. While the cellular mechanisms that underlie HR regulation are complex and still actively d...
Hyperpolarization and Cyclic Nucleotide (HCN) -gated channels represent the molecular correlates of the "funny" pacemaker current (I(f)), a current activated by hyperpolarization and considered able to influence the sinus node function in generating cardiac impulses. HCN channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channe...
OBJECTIVE To reveal the structural characteristics of the sinoatrial node (SAN) and the distribution of hyperpolarization-activated cyclic nucleotide-gated cation channels (HCN) in the SAN in the mouse. METHODS The structure of the SAN and the distribution of HCN channels in the SAN in the mouse were studied by histology and immunolabelling of ANP, Cx43 and HCN channels. RESULTS The mouse S...
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