Primary hyperparathyroidism (PHPT) is the third most common endocrinopathy seen today, and is most frequently found in the 6th to 7th decade of life. PHPT can present with various degrees of symptoms, and can affect many organ systems, including the skeletal, renal, central nervous system and cardiovascular system. Despite this, the most common presentation of hyperparathyroidism is "asymptomat...

homeostatsis and the pathophysiology of disorders associated with abnormal CaSR activity including familial hypocalciruic hypercalcemia, neonatal severe hyperparathyroidism, and secondary hyperparathyroidism. The CaSR, a member of superfamily of G-protein-coupled receptors, has a large extracelluar domain and seven membrane-spanning segments (1). This receptor is localized on the surface of var...

Asymptomatic primary hyperparathyroidism (PHPT), a condition defined as hyperparathyroidism that lacks specific symptoms or signs and with calcium levels of less than 1 mg/dL above the upper limit of normal, is a common clinical problem. Two previous conferences on the management of asymptomatic PHPT (a Consensus Development Conference and a National Institutes of Health workshop) indicated tha...

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. Clinical indicators of carcinoma include the severity of hyperparathyroidism and presence of a palpable neck mass. Definitive diagnosis requires surgical resection and specimen histology, or documentation of metastatic disease. We present a case of parathyroid carcinoma in a young female patient with severe hyperparathyroidis...

Brown tumour represents a serious complication of hyperparathyroidism. Differential diagnosis, based on histological examination, is only presumptive and clinical, radiological and laboratory data are necessary for definitive diagnosis. Here we describe a case of a brown tumour localised in the maxilla due to secondary hyperparathyroidism in a young women with chronic renal failure. Hemodialysi...