We experienced two cases of mannitol-induced hyperkalemia during craniotomy for ruptured aneurysms. Hyperkalemia was first diagnosed by peaked T wave on the ECG. Serum potassium concentration in each patient was approximately 2 mEq/l higher than the baseline value, reaching 6.0 and 5.7 mEq/l, respectively, at 2 hours after completion of infusion of 45 and 30 g mannitol, respectively. Although t...