BACKGROUND Extracts of the plant Hypericum perforatum L. have been traditionally used in folk medicine for the treatment of depressive disorders. Xanthone, a component of Hypericum perforatum L., has been shown to be effective in animal models of depression. OBJECTIVE We investigated if 2 xanthone derivatives (1101 and 1105) were as effective as venlafaxine, which is a serotonin-norepinephrin...

Extracts of Hypericum perforatum L. (St John’s wort) are now successfully Abstract competing for status as a standard antidepressant therapy. Because of this, great effort has been devoted to identifying the active antidepressant compounds in the extract. From a phytochemical point of view, St John’s wort is one of the best-investigated medicinal plants. A series of bioactive compounds has been...

Extracts of the medicinal plant St. John's wort (Hypericum perforatum) are widely used for the treatment of mild to moderate depression. Hyperforin, a constituent of St. John's wort, is known to inhibit the sodium-dependent uptake of catecholamines and amino acids into synaptic nerve endings, probably by interference with mechanisms controlling the synaptic sodium concentration. Because de novo...

Considered an antidepressant and anti-anxiety agent, Hypericum perforatum affects multiple neurotransmitters in a non-competitive synergistic manner, and may have nootropic potential. We quantitatively reviewed the pre-clinical literature to examine if there is a cognitive-enhancing effect of H. perforatum in healthy rodents. Additionally, within these studies, we compared the effects observed ...

ss Open Acce Proceedings Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci Heather J Cordell*1, Mariza de Andrade2, Marie-Claude Babron3, Christopher W Bartlett4, Joseph Beyene5, Heike Bickeböller6, Robert Culverhouse7, L Adrienne Cupples8, E Warwick Daw9, Josée Dupuis8, Catherine T Falk10, Saurabh Ghosh11, Katrina A Goddard12, Ellen L G...

The relationship between law and morality represents a major theme in jurisprudence and is the subject-matter of this article. I shall focus on the use of the criminal law to enforce morality and, in particular, I shall consider whether an identifiable line can be drawn between moral standards that may properly be the subject of legal enforcement and those that may not. This issue was, of cours...

Bartholomew's Hospital, where he had trained towards the end of the long career of John Abernethy, who attracted large numbers of students to his lectures. He had begun his medical career in the 1820s (L.S.A. 1824, M.R.C.S. 1825) and subsequently gained an F.R.C.S. by examination in 1847, and an M.D. from the University of St Andrews in 1856, during the course of his medical practice in Yeovil.