this paper represents a new region-based active contour model that can be used to segment images with intensity non-uniformity and high level noise. the main idea of our proposed method is to use gaussian distributions with different means and variances with incorporation of intensity non-uniformity model for image segmentation. in order to integrate the spatial information between neighboring ...

PURPOSE To investigate the correlation between the presence of the inactive cathepsin D (CatD) and retinal changes in mcd2/mcd2 transgenic mice. METHODS Computational modeling was used to examine whether CatD mutants maintain competitive substrate binding. D407 cells were transfected with pcDNACatDM1 or pcDNACatDM2, containing procathepsin D (pro-CatD) with 6-bp (CatDM1) or 12-bp (CatDM2) del...

PURPOSE The purpose of this study is to report an uncommon presentation of anterior and posterior scleritis with central retinal vein occlusion METHODS We report a 30-year-old female presenting with unilateral anterior and posterior scleritis with concurrent central retinal vein occlusion, the subsequent work-up, and the management. The patient presented with decreased vision and extraocular ...

Secondary metabolism in fluorescent pseudomonads is globally regulated by gacS, which encodes a membrane-bound sensor kinase, and gacA, which encodes a transcriptional response regulator. Spontaneous mutation in either gene blocked biosynthesis of the antimicrobial compounds hydrogen cyanide, 2,4-diacetylphloroglucinol, pyoluteorin, and pyrrolnitrin by the model biocontrol strain Pseudomonas fl...

PURPOSE To identify the most accurate diagnostic imaging modality for classifying pediatric eyes as papilledema (PE) or pseudopapilledema (PPE). DESIGN Prospective observational study. SUBJECTS Nineteen children between the ages of 5 and 18 years were recruited. Five children (10 eyes) with PE, 11 children (19 eyes) with PPE owing to suspected buried optic disc drusen (ODD), and 3 children ...

PURPOSE To investigate myopic choroidal neovascularization (mCNV) by fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), near-infrared (NIR) reflectance, and autofluorescence (AF). METHODS This retrospective study included 65 eyes of 62 Caucasian patients with a mean age of 66.72 years (95% confidence interval [CI] 63-70 years) and a mean refraction of -9.72 d...

BACKGROUND To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photoreceptor layers. METHODS Multimodal imaging case-series evaluating the course of atypical RPE- defects in patients with AMD using Color fundus images, Optical coherence tomograph...

Background & Aim: Medicinal plants, Since time immemorial, have been used in virtually all cultures as a source of medicine and ethnobotany has prevent to be a valuable method to find new herbal medicine and plant derived drugs. Material & Methods: This study determined medicinally important plants that are most frequently by the local inhabitants of Sistan to treat human diseases. In current ...

Background & Aim: Medicinal plants, Since time immemorial, have been used in virtually all cultures as a source of medicine and ethnobotany has prevent to be a valuable method to find new herbal medicine and plant derived drugs. Material & Methods: This study determined medicinally important plants that are most frequently by the local inhabitants of Sistan to treat human diseases. In current ...

Introduction: There are suspended fungal spores in the air and in the nasal mucosa of adults, especially in areas with a humid climate. Several studies have revealed the role of fungi in the pathogenesis of chronic rhinosinusitis (CRS) in recent years but it is a topic of controversy, especially in regions with low humidity. The aim of this study was to evaluate the prevalence of fungal specie...