We describe a case of hypercalcaemia secondary to recurrent malignant phaeochromocytoma. Parathyroid-related protein (PTHrp 1-86) immunoreactivity was identified in plasma and PTHrp was identified by immunocytochemistry in tumour tissue.

The nutrition of the very young 71 Smith, H . & Lucas, I. A. M. (1957). J. ugric. Sci. 49, 409. Speer, V., Ashton, G., Diaz, F. & Catron, D. (1953-4). Iowa Fm Sci. 8, no. 10, p. 3. Teague, H. S. & Carpenter, L. E. (1951). J. Nutr. 43, 389. Terrill, S. W. (1957). Personal communication. Venn, J. A. J., McCance, R. A. & Widdowson, E. M. (1947). J. comp. Path. 57, 314. Walker, D. M. (1948). Studie...

Hypercalcaemia is a recognised complication of hypothyroidism. We describe three patients who developed hypercalcaemia after thyroidectomy when thyroid supplements were discontinued. They were treated with thyroxine, dihydrotachysterol, and calcium after operation, and in all three cases serum calcium concentrations remained constant during combined treatment. Thyroxine treatment was discontinu...

Sarcoidosis is a disease of unknown aetiology in which cytokines such as interleukin 2 (IL-2) are thought to play an important role. We present the case history of a 48 year old man with sarcoidosis who received treatment with high dose IL-2 for metastatic renal cell cancer, following which he developed hypercalcaemia characterised by a raised level of 1,25-dihydroxyvitamin D (1,25-(OH)2-D3), a...

Human T cell lymphotrophic virus type-1 infection is endemic in the Afro-Caribbean community in Britain, with carriage rates of about 3%. Although there is a long latency, carriers have a 1-5% chance of developing adult T cell leukaemia/lymphoma, a condition frequently complicated by marked and refractory hypercalcaemia, and with a poor prognosis. We present the case of an elderly Jamaican woma...

Three patients with malignant lymphoma complicated by hypercalaemia without radiological bone abnormality are described. The medical literature has been reviewed and the possible underlying mechansims discussed. The early diagnosis of this potentially fatal complication is important since this may respond (together with the underlying disease) to appropriate chemotherapy.

In 1932 Lightwood described a child aged 2 years whose illness resembled the terminal stages of severe infantile hypercalcaemia. Later Butler (1951) and Fanconi (1951) each reported similar cases and they then discussed their findings in ajoint paper (Fanconi, Girardet, Schlesinger, Butler and Black, 1952). Since then there have been several reports of the severe form of this disease in this co...

Keywords: acute interstitial nephritis; acute renal fail-1+ proteinuria. There was no clinical evidence of foetal ure; hypercalcaemia; omeprazole distress. Omeprazole therapy was commenced.

Adult T-cell leukaemia-lymphoma is a rare haematological malignancy, which can cause severe hypercalcaemia and metastatic calcification resulting in life-threatening arrhythmias.