OBJECTIVES Improvements in perioperative pain management for lower abdominal operations has been shown to reduce morbidity, induce early ambulation, and improve patients' long-term outcomes. Dexmedetomidine, a selective alpha-2 agonist, has recently been used intrathecally as adjuvant to spinal anesthesia to prolong its efficacy. We compared two different doses of dexmedetomidine added to hyper...

Adequate analgesia following caesarean section decreases morbidity, hastens ambulation, improves patient outcome and facilitates care of the newborn. Intrathecal magnesium, an NMDA antagonist, has been shown to prolong analgesia without significant side effects in healthy parturients. The aim of this study was to evaluate the onset and duration of sensory and motor block, hemodynamic effect, po...

To the editor: It has been proposed that the intrathecal dose of hyperbaric bupivacaine for spinal anesthesia should be reduced in morbidly obese patients undergoing cesarean delivery. This recommendation is consistent with the lower volume of cerebrospinal fluid observed in patients with high body mass index, but a lack of definitive evidence has been noted. Previously, Ginosar et al. reported...

To the editor: It has been proposed that the intrathecal dose of hyperbaric bupivacaine for spinal anesthesia should be reduced in morbidly obese patients undergoing cesarean delivery. This recommendation is consistent with the lower volume of cerebrospinal fluid observed in patients with high body mass index, but a lack of definitive evidence has been noted. Previously, Ginosar et al. reported...

The analgesic effect of the centrally acting opioid, tramadol, is well-known. It has been shown in clinical studies that using tramadol epidurally can provide longer duration of analgesia, without the common side effects of opioids. The study was undertaken to evaluate the duration of analgesia and/or pain free period produced by intrathecal tramadol added to bupivacaine in patients undergoing ...

Received: November 24, 2008. Accepted: January 20, 2009. Corresponding author: Kyung-Bong Yoon, M.D., Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, College of Medicine, Yonsei University, 134, Sinchon-dong, Seodaemun-gu, Seoul 120-752, Korea. Tel: 82-2-2228-2416, Fax: 82-2-2227-7897, E-mail: [email protected] Copyright c Korean Society of Anesthesiologists...

In a double-blind study, 0.5% bupivacaine 3 ml in plain (n = 10) or hyperbaric (n = 10) solution was injected intrathecally to 20 patients who were in the sitting position, to produce spinal anaesthesia for transurethral resection of prostate. No statistically significant differences were found in time to maximum cephalad spread of analgesia nor in the level reached. However, the plain solution...

Aims and Objectives: Spinal anaesthesia is the most commonly used method of anaesthesia and analgesia in lower limb surgeries. In elderly patients spinal anaesthesia causes more sympatholysis and hemodynamic disturbances than young patients. So low dose of local anaesthetic is preferred which may occasionally cause failure of spinal anaesthesia .Therefore, different adjuvents are added to achie...

The aim of this study was to evaluate the side effects of local and systemic clinical, histopathological and hemodynamics by use of isobaric and hyperbaric bupivacaine in different concentrations during spinal anesthesia which has been a common use within the past few years. The study material consisted of 23 healthy stray dogs with dissimilar sex, age and body weight as well as bupivacaine hyd...

Low-dose bupivacaine can limit the spinal block level with minimal hemodynamic effects and yield a rapid recovery, but sometimes it may not provide adequate anesthesia for surgery. Dexmedetomidine, a selective α2-adrenoreceptor agonist, was shown to be a potent antinociceptive agent when given intrathecally in animals and humans. The purpose of this study was to evaluate the adjuvant effects of...