The usual indications for extra corporeal membrane oxygenation (ECMO) are for respiratory or cardiac failure. Although continuous renal replacement therapy (CRRT) is frequently used when patients are on ECMO, the need for CRRT as the primary indication for ECMO is rare. A case of a neonate placed onto veno-venous ECMO for the use of CRRT to treat hyperammonemia from propionic acidemia is presen...

The article reviews literature and demonstrates personal observation of a preschool patient with ornithine transcarbamylase deficiency. This disease is characterized by an excessive accumulation ammonia in the body, which leads to damage nervous system, gastrointestinal tract, impaired liver function. It has genetically determined mechanism development associated mutations OTC gene. Purpose - s...

Our study provides novel findings of experimental hypokalemia reducing urea cycle functionality and thereby severely increasing plasma ammonia. This is pathophysiologically interesting because ammonia increases during by a hitherto unknown mechanism, which may be particular important in relation to the unexplained link between hepatic encephalopathy. Potassium deficiency decreases gene expressi...