In this paper, we presented the design by computational tools of novel alkyl (2-alcoxy-2-hydroxypropanoyl)-L-tryptophanate derivatives, which can be potential inhibitors 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The molecular structure optimization a group 36 compounds was performed employing DFT-B3LYP calculations at level 6-311G(d,p). Then, docking were using Autodock software, Lama...

In order to examine the mechanism of atresia in the small follicles of laying hens, changes of three enzyme activities, acid phosphatase, 3ƒÀ-hydroxysteroid dehydrogenase (3ƒÀ-HSD) and glucose-6-phosphate dehydrogenase (G-6-PD), during atresia were analyzed histochemically. Acid phosphatase activity in the follicular wall increased along with the tissue degradation in the process of atresia. Hi...

The objective of the present study was to investigate the effects of genistein and equol on 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase 3 (17beta-HSD3) in human and rat testis microsomes. These enzymes (3beta-HSD and 17beta-HSD3), along with two others (cytochrome P450 side-chain cleavage enzyme and cytochrome P450 17alpha-hydroxylase/17-20 lyase), cat...