The aim of this study was to evaluate binders to improve the flowability of granulates and compactibility of Metformin HCL (Met) using the moist aqueous granulation (MAG) process. The effect of the binder moisture content on granulate and tablet quality was also evaluated. Vinylpyrrolidone-vinyl acetate copolymer (Kollidon VA64 fine: VA64), polyvidone (Povidone K12: PVP), hydroxypropyl cellulos...

Herein, hydroxypropyl-beta-cyclodextrin (HPβCD) inclusion complex (IC) of a hydrophobic drug, sulfisoxazole (SFS) was incorporated in hydroxypropyl cellulose (HPC) nanofibers (HPC/SFS/HPβCD-IC-NF) via electrospinning. SFS/HPβCD-IC was characterized by DSC to investigate the formation of inclusion complex and the stoichiometry of the complex was determined by Job's plot. Modeling studies were al...

Matrix-based tablets using 40 %w/w grewia gum were prepared by direct compression to contain cimetidine as novel drug. The formulations were compared with similar formulations using hydroxypropyl methylcelluose (Methocel), gum arabic, carboxy methylcellulose (Blanose), or ethyl cellulose (Ethocel) as polymer matrix. Also binary composite matrices containing grewia gum and the reference polymers...