<b>Background:</b> No results of controlled trials are available for any the few treatments offered to children with interstitial lung diseases (chILD). We evaluated hydroxychloroquine (HCQ) in a phase 2, prospective, multicentre, 1:1-randomized, double-blind, placebo-controlled, parallel-group/crossover trial. HCQ (START arm) or placebo were given 4 weeks. Then all subjects receive...

Optimized dosage regimens of hydroxychloroquine (HCQ) in coronavirus disease 2019 (COVID-19) are currently unknown. We aimed to determine that rapidly achieved the pharmacokinetic-pharmacodynamic (PKPD) target for virological clearance COVID-19 patients. Plasma HCQ concentration was simulated using a non-steady state, 2-compartment linear model. The plasma trough (Ctrough) > 0.7 mg/L used as PK...

Purpose: The effects of different COVID-19 therapeutic strategies on cardiac function are uncertain. Therefore, this study aimed to evaluate the medical treatments biventricular in patients who had recovered from COVID-19.
 Materials and Methods: Speckle-tracking echocardiography was performed examine myocardial at follow-up visits after recovery COVID-19. were divided into two groups base...

BACKGROUND Given the urgency of finding a specific treatment for coronavirus disease 2019 (COVID-19), several approaches have been carried out, including use chloroquine (CQ) and hydroxychloroquine (HCQ). This study was aimed to systematically evaluate available evidence on effectiveness HCQ in COVID-19 disease.
 METHODS We searched 3 databases (PubMed, Google Scholar, ClinicalTrials) unti...

Graphene Oxide (GO) is known to have two faces: it has many benefits; and hazardous our health. This study understood the jeopardizing effects of GOs in body, wanted find out a way remove body. Three sets observational studies were done evaluate detoxifying MMS2 (Calcium Hypochlorite), Hydroxychloroquine (HCQ), ivermectin, GNP (Gold Nanoparticle) + Camostat Mesylate (Foipan) on human plasma. so...

The completion A[τ ] of a locally convex ∗-algebra A[τ ] with not jointly continuous multiplication is a ∗-vector space with partial multiplication xy defined only for x or y ∈ A0, and it is called a topological quasi ∗-algebra. In this paper two classes of topological quasi ∗-algebras called strict CQ-algebras and HCQ-algebras are studied. Roughly speaking, a strict CQ-algebra (resp. HCQ-algeb...

Background: The American Academy of Ophthalmology recommendations for screening of chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy were published in 2002, but improved screening tools and new knowledge about the prevalence of toxicity have appeared in the ensuing years. No treatment exists as yet for this disorder, so it is imperative that patients and their physicians be aware of the...

Um surto do novo coronavírus (COVID-19) teve início em dezembro de 2019 e se espalhou pela China, alastrando-se pelo mundo pouco tempo, o que requer pesquisas imediatas para seu tratamento. Assim, uso cloroquina (CQ) hidroxicloroquina (HCQ) tem despertado interesse no COVID-19. Esta revisão sistemática segue os itens relatório indicados revisões sistemáticas Diretrizes Meta-Análise (PRISMA). Os...

ORIGINAL PAPER SUMMARY In 2 years study, at Rheumatologic Department of University Clinic Centre in Pristina, it was done application of combined therapy with Methotrexate (tablets Methotrexate of 15 mg weekly, Sulphasalazine 2g daily, Hydroxychloroquine 400 mg) to patients with rheumatoid arthritis. Methods: During our investigation were treated 20 patients, 18 females and 2 males, in the trea...

BACKGROUND The American Academy of Ophthalmology recommendations for screening of chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy were published in 2002, but improved screening tools and new knowledge about the prevalence of toxicity have appeared in the ensuing years. No treatment exists as yet for this disorder, so it is imperative that patients and their physicians be aware of the ...