Three new lignans, sambucunol A (8) ((+)-erythro-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-hydroxyphenoxy]-1, 3-propanediol), sambucunol B (9) ((+)-threo-1-(4-hydroxyl-3-methoxyphenyl)-2-[4-(4-hydroxy-3-methoxy-cinnamoyloxy propanyl)-2-hydroxyphenoxy]-1, 3-propanediol) and buddlenol G (10) (2-{4-[2, 3-dihydro-3-hydroxymethyl-7-hydroxy-5-(4-hydroxy-3-methoxyc...

The present work describes the novel synthesis of 3, 3'-((phenyl) (ethylamino) methyl)-4-hydroxy-2H-chromen-2-one derivatives catalyzed by biogenic ZnO nanoparticles. synthesized heterocyclic compounds were characterized fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) andmass spectrometric techniques. Absorption, distribution, metabolism and excretion propertie...

Azobenzene macrocycles were designed for switchable π-stacking interaction. After efficient preparation and characterization of azobenzene macrocycles containing electron rich as well as electron poor elements a dimeric analogue was synthesized, which formed reversibly 3D-networks. Gel formation was observed with aromatic solvents representing the first example of this type based on switchable ...

introduction: antioxidants are compounds that eliminate free radicals, which reduce tissue damage and allow the organs and blood vessels to properly heal. in this research, the anticancer effect against mcf-7 and ht-29 cell lines, and antioxidant, antimicrobial and wound healing activities of the lichens extracts have been investigated. materials and methods: anticancer activity was assayed wit...

In the title compound, C(18)H(15)ClN(4)O(2)S, the pyrazole ring makes dihedral angles of 67.4 (1) and 12.5 (1)° with the phenyl and 4-hydroxy-phenyl groups, respectively; the two benzene rings are twisted by 60.1 (1)° with respect to each other. The thio-urea NH groups are involved in N-H⋯O and N-H⋯Cl intra-molecular hydrogen bonds. A hydrogen bond between the phenolic OH group and the pyrazole...

The synthesis and structural determination of two new diterpenylhydroquinones: 2beta-acetoxy-15-phenyl-(22,25-dihydroxy)-ent-labda-8(17),13(E)-diene(1) and 2beta-hydroxy-15-phenyl-(22,25-dihydroxy)-ent-labda-8(17),13(E)-dieneis reported (2). These compounds were obtained by coupling via Electrophilic Aromatic Substitution (EAS) of 1,4-hydroquinone with primary or tertiary allyl alcohol derivati...

The excited-state behavior of 9-hydroxy-10-methyl-9-phenyl-9,10-dihydroacridine and its derivative, 9-methoxy-10-methyl-9-phenyl-9,10-dihydroacridine (AcrOR, R = H, Me), was studied via femtosecond and nanosecond UV-vis transient absorption spectroscopy. The solvent effects on C-O bond cleavage were clearly identified: a fast heterolytic cleavage (τ = 108 ps) was observed in protic solvents, wh...

180 words Introduction: 873 words Discussion: 1726 words Abbreviations: AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid), CMPDA (a phenyl-1,4-bis-alkylsulfonamide), CMPDB (a phenyl-1,4-bis-carboxythiophene), deact (deactivation), des (desensitization), CTZ (cyclothiazide), CX614 (pyrrolidino-1,3-oxazino benzo1,4-dioxan-10-one), LBC (ligand-binding core), PDB (Protein Data Bank) ...

SUMMARY The c arcinogenicity of N-hydroxy-2-fluorenyl benzenesulfonamide (N-HO-2-FBS), a potent carcinogen for the young male and female rat by i.p. administration, was confirmed by p.o. administration of the compound to the adult male rat. The compound produced hepatic lesions that were macroscopically and microscopically very similar to those induced by N-hydroxy-2-fluorenylacetamide. Examina...