Daily administration of sodium biphenyl hydantionate (Dilantin) to rats has been shown to increase markedly the dermal concentration of insoluble collagen and non-collagenous protein (1) as well as to decrease the concentration of both tissue water and fat (2). These effects were produced by ten or more daily doses of 100 mg of drug per kg body weight (3) and were a result of the specific struc...

INTRODUCTION Planorbis planorbis (Ram's Horn Snail) is a species of air-breathing freshwater snail, an aquatic gastropod mollusk in the family Planorbidae. It is one of the most common freshwater snails in Europe, occurs in numerous water body types with a preference for standing water such as ponds, swamps or lakes with slow moving or stagnant waters. As typical freshwater invertebrate it is c...

4-Hydroxyphenylmethylene hydantoin (PMH, 1), isolated from the Red Sea sponge Hemimycale arabica, and delta-tocotrienol (3), isolated from the tocotrienol-rich fraction of palm oil, are important antimetastatic and antiproliferative natural products that proved effective against metastatic prostate and breast cancers, respectively. New fluorescent derivatives of PMH (2) and delta-tocotrienol (4...

Dissolution behaviour of both 5, 5-diphenyl hydantoin sodium commonly known as dilantin sodium (DS) and its corresponding marketed capsule dilantin have been studied in aqueous as well as micellar media. Percentage dissolution of both DS and its marketed capsule are found to be low as expected in aqueous medium due to its very low solubility in water. However, their dissolution tendency is foun...

A quantitative structure property relationship investigation was performed on the lipophilicities of a number of hydantoin derivatives as measured by the RP-HPLC retention times provided by Scholl et al. (Scholl, S.; Koch, A.; Henning, D.; Kempter, G.; Kleinpeter, E. Struct. Chem. 1999, 10, 355-366). The lipophilicities (S) were correlated with the theoretical molecular descriptors of the hydan...

Radiolysis products resulting from the deamination pathway were isolated and identified after irradiation of cytosine by gamma rays in neutral aqueous solutions. They were identical to those identified in uracil radiolysis i. e. 5,6-dihydroxy-5,6-dihydro-uracil (cis and trans forms), iso-dialuric acid, alloxan, 5-hydroxy-hydantoin, parabanic acid and oxaluric acid. The absence of 4,4'-di-iso-ba...