Transplantation of the kidney, liver, or heart is now a well established and successful treatment for irreversible organ failure. It has been much more difficult to achieve success in intestinal transplantation, although experimental and clinical work has been carried out in this field since the late 1950s. However, in the last three years there have been several successful human small bowel tr...

conclusions educating health promotion strategies was effective in improving self-care self-efficacy in patients undergoing kidney transplantation. establishment of a holistic caring program is suggested to integrate the pre-transplantation educations with a continual post discharge follow-up. results in the intervention group, the mean of total self-care self-efficacy was 106.96 ± 25.1 at firs...

loss of hearing is a known problem in patients with chronic renal failure, occurring in 40-xo% of cases and being most often of the high frequency sensorineural type. we performed a study on 50 patients with this disease, including 20 who had undergone a successful kidney transplantation. our results show an 80% incidence of hearing loss in these patients and a chance of improvement in at least...

objectives the aim of this study was to investigate the possible associations between co-stimulatory molecule gene polymorphisms and viral infections in kidney transplant patients. results cmv active infection was found in 31 of 172 (18.02%) kidney transplant patients. hcv infection was only found in two of the 172 (1.16%) studied patients. significant associations were found between tt and tc ...

background: thymoglobuline (tg), is used for both induction and rejection therapy in kidney transplantation (tx). this study was conducted to compare between adding tg or not to the conventional drugs to evaluate the rate of rejections, infections and costs. methods: in two groups of patients, each of 45 cases group a received conventional drugs (cyclosporine, mycophenolate and prednisolone) an...

Correspondence: Helena Sá [email protected] Hospital da Universidade de Coimbra. Praceta Mota Pinto 3000-075 Coimbra. Portugal INTRODUCTION Mycophenolate mofetil (MMF), the first pharmaceutical prodrug of mycophenolic acid (MPA) that received approval for human clinical use, has been utilised in solid organ transplantation since 1995, particularly in kidney transplantation. MMF launchin...

BACKGROUND Hypertension persists in many patients with diabetes mellitus after kidney transplantation. However, the impact of control of diabetes as well as kidney failure on hypertension by combined kidney and pancreas transplantation has not been studied. METHODS AND RESULTS Between March 1993 and August 1998, 111 patients with type 1 diabetes mellitus underwent successful pancreas transpla...

While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to kidney injury induced by ischemia and reperfusion, the relevance of TLR4 activation to allograft injury in human kidney transplants is unknown. Here we show that TLR4 is constitutively expressed within all donor kidneys but is significantly higher in deceased-, compared with living-donor organs. Tubules from dece...

Pancreas Transplantation aims at providing Beta cells replacement in diabetic patients, especially for type 1 diabetes recipients in whom Beta cells had been destroyed by an autoim‐ mune process. The final achievement is to restore a normal physiological control of glucose metabolism in order to halt or reverse the secondary complications of diabetes i.e. retinopathy, neuropathy, nephropathy, m...

objective(s):recently cell therapy is a promising therapeutic modality for many types of disease including acute kidney injury (aki). due to the unique biological properties, mesenchymal stem cells (mscs) are attractive cells in this regard. this study aims to transplant mscs equipped with nuclear factor e2-related factor 2 (nrf2) in rat experimental models of acute kidney and evaluate regenera...