نتایج جستجو برای: human immunization
تعداد نتایج: 1669910 فیلتر نتایج به سال:
Introduction The human respiratory syncytial virus (hRSV) is responsible for most tract infections in infants. Even though currently there are no approved hRSV vaccines newborns or infants, several candidates being developed. rBCG-N-hRSV a vaccine candidate previously shown to be safe phase I clinical trial adults ( clinicaltrials.gov identifier #NCT03213405). Here, secondary immunogenicity ana...
The in vivo and in vitro immune response after in vivo immunization with pneumococcal polysaccharides (PPS) has been analyzed in man. Substantial differences were noted in this system when compared with human responses to soluble protein antigens. Within 6 d after immunization, specific PPS antigen-binding cells (ABC), specific plaque-forming cells (PFC), and cells capable of spontaneously synt...
Immune responses to some monoclonal antibodies (mAbs) and biologic proteins interfere with their efficacy due to the development of anti-drug antibodies (ADA). In the case of mAbs, most ADA target 'foreign' sequences present in the complementarity determining regions (CDRs). Humanization of the mAb sequence is one approach that has been used to render biologics less foreign to the human immune ...
A highly efficacious pre-erythrocytic stage vaccine would be an important tool for the control and elimination of malaria but is currently unavailable. High-level protection in humans can be achieved by experimental immunization with Plasmodium falciparum sporozoites attenuated by radiation or under anti-malarial drug coverage. Immunization with genetically attenuated parasites (GAP) would be a...
vaccination considered as one of the most cost-effective health interventions worldwide through prevention and control of many serious childhood diseases (1). it is estimated global coverage of dose 3 of diphtheria, tetanus, and pertussis (dtp3)among children one year old has been 86% in 2014 (by range from 77% to 96% in african region and western pacific region; respectively) (2). globally...
Introduction: Glycoprotein B (gB) is the major antigen for induction of humoral responses against human cytomegalovirus (HCMV) making it an attractive candidate for immune prophylaxis. In the present study, the humoral immune response of BALB/c mice to a truncated HCMV gB protein fused with GFP was evaluated. Methods: The truncated gB coding sequence was synthesized and cloned in pEGFPN1 eukary...
Background: Despite the effective pre- and post-exposure treatments, at least 60,000 deaths from rabies occur worldwide every year. Post-exposure treatment is considered as one of the most significant measures for preventing human deaths in exposed individuals. The 2-1-1 rabies post-exposure treatment schedule known as Zagreb regimen is an abbreviated immunization plan in which a tissue cultu...
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